Objective：To observe the curative effect of Duzhong granules combined with calcitonin salmon injection on the basis of routine western therapy for primary osteoporosis(POP)with liver and kidney deficiency syndrome.Methods：Selected 116 cases of patients with liver and kidney deficiency syndrome and divided them into the control group and the treatment group randomly，58 cases in each group.Both groups received routine intervention of adjusting lifestyle and taking moderate exercise.The control group received calcium carbonate and vitamin D3 tablets and alendronate sodium tablets orally for treatment，while the treatment group additionally received Duzhong granules combined with calcitonin salmon injection based on the treatment of the control group.Both groups received treatment for 6 months.Compared changes of symptom scores of liver and kidney deficiency syndrome and levels of bone mineral density(BMD)，and sclerostin(SOST)and Dickkopf-1(DKK-1)in serum of patients in both groups before and after treatment.Evaluated the clinical effect after treatment.Results：The total effective rate was 96.55%in the treatment group，being higher than that in the control group which was 82.76%，the difference being significant(P ＜ 0.05).Scores of pain in lumbar and spine，difficulty in walking，dizziness，soreness and weakness as well as myasthenia in both groups were all decreased when compared with those before treatment(P＜0.01).Each scores above in the treatment group were lower than those in the control group(P＜0.01).The BMD value of anterial position of lumbar spine(L2～4)and right neck of femur in both groups was all increased when compared with that before treatment(P＜0.01).The two BMD value in the treatment group was higher than that in the control group(P＜0.01).Levels of SOST and DKK-1 in serum in both groups were all decreased when compared with those before treatment(P＜0.01).Levels of the above two indexes in the treatment group were lower than those in the control group(P＜0.01).Conclusion：The therapy of Duzhong granules combined with calcitonin salmon injection on the basis of routine western therapy has definite curative effect in treating POP with liver and kidney deficiency syndrome，which can effectively improve clinical symptoms and promote bone formation of patients.Reducing the levels of SOST and DKK-1 in serum of patients probably is one of the therapeutic approaches，which is worthy of further discussion.