Objective： To observe the clinical effect of Huangqi Guizhi Wuwu tang for carpal tunnel syndrome of qi-deficiency and blood-stasis type.Methods： This was a non-randomized controlled study.Selected 60 patients， and divided 72 cases of carpals into the treatment group of Huangqi Guizhi Wuwu tang being 37 cases and the control group being 35 cases randomly.The treatment group received Huangqi Guizhi Wuwu tang for treatment，while the control group was given mecobalamine for treatment.Compared such status as functional status score，therapeutic evaluation and electromyography in two groups.Results： After treatment， compared functional status score and each index of electromyography(included)in the two groups with those before treatment，there were significant differences being found(P ＜0.01，P＜0.05).There were significant differences being found in the comparisons of functional status scores and each index of electromyography between the two groups(P＜0.05).There was significant difference being found in the comparison of the clinical effect within the two groups(P＜0.05).Conclusion：Huangqi Guizhi Wuwu tang can effectively treat carpal tunnel syndrome of qi-deficiency and blood-stasis type，which is worthy of clinical application.