Objective：To observe the clinical effect of modified Xiaoke Jianpi tang combined with western medicine for patients with type 2 diabetes mellitus(T2DM)of spleen deficiency with excessive dampness type.Methods：Selected 72 cases of patients with T2DM of spleen deficiency with excessive dampness type and divided them into two groups according to random number table method，36 cases in each group.The control group only received western medicine for treatment which included rosiglitazone hydrochloride tabletsand metformin hydrochloride tablets，while the observation group additionally received modified Xiaoke Jianpi tang based on the treatment of the control group.Both groups continuously received treatment for 4 weeks.Compared blood glucose indexes which included fasting blood glucose(FBG)，glycosylated hemoglobin(HbA1c)and postprandial 2 h blood glucose(P2hBG)as well as levels of serum adiponcetin and visfatin in both groups before treatment and after four weeks of treatment.Compared the curative effect and incidence of adverse reaction in both groups.Results：After treatment of four weeks，the total effective rate was 91.67%in the observation group，higher than that in the control group，which was 69.44%，the difference being significant(P＜0.05).Levels of FBG，HbA1c and p2hBG in both groups were decreased when compared with those before treatment(P＜0.05).Levels of the above indexes in the observation were lower than those in the control group(P＜0.05).Levels of serum adiponcetin in both groups were increased when compared with those before treatment(P ＜ 0.05)，while levels of serum visfatin were decreased when compared with those before treatment(P＜0.05).Levels of serum adiponcetin in the observation group were higher than those in the control group(P＜0.05)，while levels of serum visfatin were lower than those in the control group(P＜ 0.05).No significant difference was found in the comparison of incidence of adverse reaction between the two groups during treatment(P＞0.05).Conclusion：The therapy of modified Xiaoke Jianpi tang combined with western medicine has a significant effect in treating patients with T2DM of spleen deficiency with excessive dampness type，which can obviously improve levels of blood glucose，adiponcetin and visfatin as well as relieve insulin resistance with high safety.