Objective：To observe the effect of the therapy of Yiyin Xiaoke tang co mbined with intensive insulin on blood glucose fluctuation in patients of inadequate blood-glucose controll with type 2 diabetes mellitus(T2DM).Methods：Selected 120 cases of T2DM patients with inadequate blood-glucose control，and divided them into the control group and the observation group randomly，60 cases in each group.The control group was given intensive insulin for treatment，while the observation group was additionally given Yiyin Xiaoke tang based on the treatment of the control group.Observed and compared the changes of fasting blood glucose(FBG)，postprandial 2-hour blood glucose(P2hBG)and glycosylated hemoglobin(HbA1c)before and after treatment in the two groups.Recorded the time of blood glucose reaching standard and incidence of hypoglycemia.Results：After treatment，levels of FBG，P2hBG and HbA1c were decreased when compared with those before treatment，differences being significant(P ＜ 0.05).Levels of FBG，P2hBG and HbA1c in the observation group were lower than those in the control group，differences being significant(P＜0.05).The time of blood glucose reaching standard in the observation group was shorter than that in the control group，the difference being significant(P＜0.05).The incidence of hypoglycemia was 5.00%in the observation group and was 25.00%in the control group，the difference being significant(P＜0.05).Conclusion：The therapy of Yiyin Xiaoke tang combined with intensive insulin for T2DM patients with inadequate blood-glucose control has a significant effect on controlling blood glucose and can reduce reactions of hypoglycemia.