Objective：To observe the clinical effect of Gexia Zhuyu tang combined with western medicine for liver cirrhosis with blood stasis of liver and spleen syndrome.Methods：Selected 72 cases of patients with liver cirrhosis with blood stasis of liver and spleen syndrome as study subjects，and divided them into the observation group and the control group according to random number table method，36 cases in each group.The control group was simply given western medicine for treatment，while the observation group was additionally given Gexia Zhuyu tang based on the treatment of the control group.Observed the changes of Chinese medicine syndrome scores，liver function indexes aspartate aminotransferase(ALT)，alanine aminotransferase(AST)，albumin(Alb)，total bilirubin(TBil)and liver fibrosis indexes including procollagen Ⅲ propeptide(PⅢP)，haluronic acid(HA)，laminin(LN)and Ⅳ type collagen(Ⅳ-C)in two groups before and after treatment.Compared the clinical effect in both groups.Results：After treatment，scores of lateral thorax stabbing pain，abdominal distension，spider nevus，dim complexion，fatigue and weakness，and poor appetite as well as the total scores of Chinese medicine syndrome in both groups were all decreased when compared with those before treatment(P＜0.05).Each Chinese medicine syndrome score and the total scores of Chinese medicine syndrome in the observation group were lower than those in the control group(P＜0.05).The total effective rate was 91.67%in the observation group and was 66.67%in the control group，the difference being significant(P＜0.05).Levels of AST，ALT and TBil in both groups were decreased when compared with those before treatment，while Alb levels were increased，differences being significant(P ＜ 0.05).Levels of AST，ALT and TBil in the observation group were lower than those in the control group(P ＜ 0.05)，while the Alb levels were higher than those in the control group(P＜0.05).Each value of liver fibrosis indexes in two groups was decreased when compared with that before treatment(P ＜ 0.05)，and each value of liver fibrosis indexes in the observation group was lower than that in the control group(P＜0.05).Conclusion：Compared with the application of Gexia Zhuyu tang based on treatment of western medicine for liver cirrhosis with blood stasis of liver and spleen，simple western medicine can more effectively relieve clinical symptoms and improve the liver function and liver fibrosis of patients，which has significant clinical effect.