Objective：To observe the effect of method of removing blood stasis and detoxification on patients of septic shock with hemodynamic disorders.Methods：66 cases of patients with septic shock were included in a prospective study and they were divided into the group of removing blood stasis and detoxification being 35 cases and the control group being 31 cases randomly.The control group received routine therapy according to the guide of 2012，while the group of removing blood stasis and detoxification was additionally treated with Xuebijing injection.Observed and recorded C-reactive protein(CRP)，procalcitonin(PCT)，and lactic acid(LAC)of patients in both groups.For patients monitored by PiCCO，hemodynamic parameters and the amount of norepinephrine were recorded.Recorded coagulation function and 28-day survival rate of patients in two groups.Results：On the 5thday of treatment，SOFA scores in the the group of removing blood stasis and detoxification were obviously lower than those in the control group.The level of CRP in the group of removing blood stasis and detoxification showed a trend of decreasing，while it showed a trend of increasing in the control group，difference being significant(P ＜ 0.05).After five days of treatment，activated partial thromboplastin time(APTT)in the group of removing blood stasis and detoxification decreased，while the APTT in the control group increased，difference being significant(P ＜ 0.05).28-day survival rate was 85.7%in the the group of removing blood stasis and detoxification，being higher than 57.7%in the control group，difference being significant(P ＜ 0.05).At the 4th，12th，24th，48th，72thhour and 5thday of treatment，the amount of norepinephrine between two groups，difference being insignificant(P ＞ 0.05).On the 5thday of treatment，there were no significant differences being found in the comparisons of PCT，LAC，blood coagulation index，blood platelet count(BPC)，prothrombin time(PT)，and fibrinogen(FIB)between two groups(P ＞ 0.05).Fifteen patients with septic shock were monitored with PiCCO due to their illness condition，including 10 cases in the group of removing blood stasis and detoxification and 5 cases in the control group.Comparing the group of removing blood stasis and detoxification with the control group，there were no significant differences being found in the comparisons of peripheral circulation resistance(SVR)and peripheral circulation resistance index(SVRI)at the 0th，24th，and 48thhour in the treatment(P ＞ 0.05).Conclusion：The method of removing blood stasis and detoxification can improve the 28-day survival rate of patient，and has a significant effect in improving hemodynamics and reducing vasoactive drug application，without increasing the risk of bleeding.