Objective： To observe the clinical effect and safety of Huachang Tongbian tablets combined with Jianwei Yichangning for senile slow transit constipation.Methods：Divided 62 cases of patients with slow transit constipation into two groups randomly.The treatment group received homemade formulations of Huachang Tongbian tablets combined with Jianwei Yichangning for treatment，while the control group received polyethylene glycol 4000 powder for treatment.Observed the clinical effect in both groups.Results：The difference was significant when compared the total effective rates between two groups(P＜0.05).The difference was significant when compared the clinical effect between two groups after drug withdrawal(P＜0.05).Conclusion：The therapy of Huachang Tongbian tablets combined with Jianwei Yichangning for senile slow transit constipation has significant clinical effect that maintains a long time，and it is a safe and reliable treatment，which is worthy of clinical application.