Objective：To observe the clinical effect of Xieqing pills combined with Shengjiang powder for insomnia and anxiety of syndrome of liver depression transforming into fire.Methods：Divided 80 cases of patients with insomnia and anxiety of syndrome of liver depression transforming into fire into the observation group and the control group randomly，40 cases in each group.The control group was given alprazolam tablets for treatment，while the observation group was given Xieqing pills combined with Shengjiang powder for treatment.The treatment lasted for two weeks in both groups.Compared the clinical effect in two groups and evaluated anxiety and quality of sleep by applying Hamilton anxiety scale(HAMA)and Pittsburgh sleep quality index(PSQI).Results：The total effective rate was 95.0%in the observation group and was 92.5%in the control group，difference being insignificant(P ＞ 0.05).After treatment，physical anxiety scores，psychological anxiety scores，and the total scores of HAMA in both groups were all decreased when compared with those before treatment(P ＜0.05).The physical anxiety scores，psychological anxiety scores，and the total scores of HAMA in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，scores of the quality of sleep，the time of falling asleep，sleep time，sleep efficiency，sleep disorder，and daytime dysfunction in both groups were all decreased when compared with those before treatment(P ＜ 0.05).The scores of quality of sleep，the time of falling asleep，sleep time，and sleep efficiency in the control group were all lower than those in the observation group(P＜0.05).There were no significant differences being found in the comparisons of scores of sleep disorder and daytime dysfunction in both groups(P＞0.05).The adverse reaction rate was 5.0%in the observation group and was 20.0%in the control group，difference being significant(P＜0.05).Conclusion：The therapy of Xieqing pills combined with Shengjiang powder can effectively improve symptoms of patients with insomnia and anxiety of syndrome of liver depression transforming into fire.