Objective： To observe the clinical effect of modified Sanhua tang combined with routine therapy for acute cerebral hemorrhage and its effect on the serum levels of interleukins(IL)-6 and tumor necrosis factor(TNF)-α.Methods：Selected 100 cases of patients with acute cerebral hemorrhage along with syndrome of phlegm-heat and fu-organ sthenia，wind-phlegm stagnation，and divided them into the treatment group and the control group randomly，50 cases in both groups.Both groups were given the routine symptomatic treatment，while the observation group additionally received modified Sanhua tang for treatment，and the course of treatment for both groups lasted for 2 weeks.Compared Glasgow Coma Scale(GCS)scores，National Institute of Health Stroke Scale(NIHSS)scores，Chinese medicine syndrome scores，the serum levels of IL-6 and TNF-α and the clinical effect in the two groups before and after treatment.Results： After treatment，the total effective rate was 92.00%in the treatment group，higher than 74.00%in the control group，difference being significant(P ＜ 0.05).GCS scores in both groups were higher than those before treatment，and NIHSS scores were lower than those before treatment，differences being significant(P ＜ 0.01).Comparing with the control group，GCS scores in NIHSS scores in the treatment group were lower significantly，differences being significant(P ＜ 0.01).The scores of headaches，dizziness，abundant sputum，dry stool or constipation，yellowish fur and dark red tongue in both groups were lower than those before treatment(P ＜ 0.01)；comparing with the control group，the scores of each symptom in the treatment group were decreased more evidently(P＜0.01).The serum levels of IL-6 and TNF-α in both groups were lower than those before treatment(P ＜ 0.01)；comparing with the control group，the serum levels of IL-6 and TNF-α in the treatment group were decreased more evidently(P＜0.01).Conclusion：Modified Sanhua tang combined with routine therapy has significant clinical effect in treating acute cerebral hemorrhage with syndrome of phlegm-heat and fu-organ sthenia，wind-phlegm invading upward has definite clinical effect in relieving inflammatory reactions in the body，and it can effectively promote the recovery of neurologic impairment and the improvement of conscious state，which is worthy of further discussing.