Pancreatic fibrosis，the main pathological feature，is caused by a variety of etiologies of chronic pancreatitis.It is still lacking Chinese and western medicines that have the exact clinical effect.The authors reviewed the research progresses of Chinese medicine on the five key signal pathways(TGF-β/Smad，MAPK，NF-κB，JAK/STAT，Hedgehog)involving the treatment of pancreatic fibrosis，so as to provide reference for the further study of the mechanism of Chinese medicine in treating chronic pancreatitis with pancreatic fibrosis.