Objective：To observe the clinical effect of modified Liuwei Dihuang tang for chronic eczema of yin deficiency of liver and kidney type.Methods：Divided 200 cases of patients diagnosed as chronic eczema of yin deficiency of liver and kidney type into the observation group and the control group randomly according to random envelope allocation method，100 cases in each group.The observation group receivedmodified Liuwei Dihuang tang for treatment，while the control group was given cetirizine for treatment.Both groups received the external application of Qingpeng ointment.Evaluated skin lesions of patients by using eczema area and severity index rating scale(EASI)，and compared EASI score，itching score，clinical effect and recurrence rate in two groups.ResultsThe total effective rate of clinical effect was 97.00%in the observation group and 88.00%in the control group，difference being significant(P ＜ 0.05).After treatment，EASI score and itching score in the observation group were obviously lower than those in the control group，differences being significant(P＜0.05).After follow-up of 3 months，recurrence rate in the observation group was 16.9%，being evidently lower than 34.9%in the control group，difference being significant(P＜0.05).Conclusion：The short-and long-term clinical effect of modified Liuwei Dihuang tang for chronic eczema of yin deficiency of liver and kidney type is better than Cetirizine.Each index score improves significantly，and the recurrence rate is low.