objective：To observe the clinical effect of modified Yinchenhao tang combined with cisplatin intraperitoneal perfusion for ascites hepatoma and effect on natural killer cell(NK).Methods：Divided 90 cases of patients with liver cancer merged with ascites into two groups，45 cases in each group.The control group receivedcisplatin peritoneal injection for chemotherapy，while the treatment group was given oral administration of modified Yinchenhao tang.Evaluated Chinese medicine syndromes before and after treatment，and collected blood to detect aspartate transferase(AST)，alanine transferase(ALT)， and alpha-fetoprotein(AFP)， to detect NK cell activity of peripheral blood mononuclear cells(PBMC)， and to detect CD4+/CD8+of ascites，NK cell count before and after treatment.Results：After treatment，the total effective rate of curative effect of Chinese medicine syndrome was 68.9%in the treatment group and 42.2%in the control group，difference being significant(P ＜ 0.05).After treatment，differences were significant when respectively compared AST，ALT，AFP，CD4+/CD8+of ascites，NK cell count in both groups with those before teatment(P＜ 0.05，P＜ 0.01).ConclusionModified Yinchenhao tang can reduce the symptoms of patients with ascites hepatoma and enhance the vitality of NK cells.It has a significant clinical effect.