Objective： To observe the clinical effect of Huamo ointment combined with Duhuo Chushi tang for acute traumatic synovitis of knee joint.Methods：Divided 102 cases of patients with acute traumatic synovitis of knee joint into the control group and the observation group randomly according to random number table，51 cases in each group.Based on routine treatment，the control group receiveddiclofenac sodium combined with Huamo ointment for treatment，while the observation group received Huamo ointment combined with Duhuo Chushi tang.Observed Chinese medicine syndrome scores，knee joint function as well as clinical effect，and detected levels of serum interleukin-1(IL-1)and tumor necrosis factor-α (TNF-α)in both groups.Results：After treatment， Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment；scores of knee score scale(Lysholm)in function，pain，range of motion and malformation were increased when compared with those before treatment；levels of serum IL-1 and TNF-α were decreased when compared with those before treatment，differences being significant(P ＜ 0.05).Chinese medicine syndrome score in the observation group was lower than that in the control group(P＜0.05).Scores of knee score scale in function，pain，range of motion and malformation were higher than those in the control group(P＜ 0.05).Levels of serum IL-1 and TNF-α were lower than those in the control group，the difference being significant(P＜0.05).The total effective rate of clinical effect was 88.24%in the observation group and was 72.55%in the control group，the difference being significant(P＜0.05).Conclusion：The therapy of Huamo ointment combined with Duhuo Chushi tang can effectively improve knee joint function and levels of serum IL-1 and TNF-α of patients with acute traumatic synovitis of knee joint，which improves clinical effect.