Objective：To observe the effectiveness and safety of applying Dingtong ointment for acute and chronic pain of orthopedics department.MethodsReviewed and analyzed medical records of 100 patients with acute and chronic pain of orthopedics department in our hospital，and divided them into the treatment group being 70 cases which receivedDingtong ointment for treatment，and the control group being 30 cases which received compound Nanxing Zhitong ointment.Analyzed curative effect in two groups and the changes of scores of visual analogue scales(VAS)and clinical symptoms.ResultsIn the 3rdday of treatment，the scores of VAS and clinical symptoms in both groups were reduced in comparison with those before treatment，differences being significant(P ＜ 0.05)；in the 7thday of treatment，these two scores in both groups were declined in comparison with those in the 3rd day of treatment，differences being significant(P ＜ 0.05).No difference was found when comparing the differences of the two scores in both groups before and after treatment(P＞0.05).The total effective rate was 94.29%in the treatment group and was 96.67%in the control group，the difference was not statistically significant(P＞0.05).There was one case of patient with itch of skin being found in the treatment group，which got spontaneous remission after shortening the application time.Conclusion：Applying Dingtong ointment for acute and chronic pain in orthopedics departmen thas good curative effect and safety.