Objective：To observe the clinical effect of Guilong tang combined with western medicine in treating patients with diabetic foot and its influence on hemorheology and vascular endothelial cell function.Methods：Divided 160 cases of patients with diabetic foot of yang deficiency and blood-stasis type into group A，B and C randomly，and each group receivedGuilong tang，western medicine and Guilong tang combined with western medicine respectively for treatment.Compared the clinical effect of the three groups 3 months after treatment and the incidence of adverse reaction during the treatment，and observed the changes of hemorheological indexes[high shearrate blood viscosity(HBV)，low shearrate blood viscosity(LBV)，plasma viscosity(PV)，whole blood reduction viscosity(WBRV)，hematocrit(HCT)]and functional indexes of vascular endothelial cell function[soluble endothelial protein C receptor(sEPCR)，von Willebrand factor(vWF)].Results：After treatment，the total effective rate of group A and B was compared，differences being insignificant(P ＞ 0.05)；the total effective rate in group C was higher than that in group A and B，differences being significant(P＜ 0.05).HBV，LBV，PV，WBRV and HCT of group A and B were compared，differences being insignificant(P ＞ 0.05)；HBV，LBV，PV，WBRV and HCT of group C were all lower than those in group A and B，differences being significant(P＜0.05).sEPCR and vWF in group C were both lower than those in group A and B，differences being significant(P＜0.05).The incidence of adverse reaction in the three groups were compared，differences being insignificant(P ＞ 0.05).Conclusion：Guilong tang combined with western medicine has definite clinical effect in treating diabetic foot of yang deficiency and blood-stasis type，and has significant synergistic function when comparing with western medicine treatment.Its mechanism may be related to the improvement of hemorheology and vascular endothelial cell function.Without increasing adverse reaction，it has a high clinical value.