To observe the clinical effect of integrated Chinese and western medicine therapy for acute pancreatitis.Methods：Divided 120 cases of patients admitted in our hospital into the control group and the observation group randomly，60 cases in each group.Both groups were given routine western medicine for treatment，while the observation group was additionally given oral administration of Chinese medicine.After treatment，compared the clinical effect in both groups，recorded the recovery time of leukocytes，serum amylase and urine amylase，and observed the improvement of pain of patients.Results：The total effective rate was 81.67%in the control group and was 95.00%in the observation group，the difference being significant(P＜0.05).The recovery time of leukocytes，serum amylase and urine amylase in the observation group was shorter than that in the control group(P ＜ 0.05).Before treatment，no significant difference was found in the comparison of VAS scores between the two groups(P ＞ 0.05).After treatment，VAS scores in both groups were decreased when compared with those before treatment(P＜0.05).The VAS scores in the observation groups were lower than those in the control group(P＜0.05).Conclusion：The therapy of integrated Chinese and western medicine therapy for acute pancreatitis can effectively relieve clinical symptoms of patients and improve the curative effect.