To observe the curative effect of integrated Chinese and western medicine therapy for patients with vascular dementia of syndrome of orifices confused by phlegm.Methods：Selected 90 cases of patients with vascular dementia of syndrome of orifices confused by phlegm，and divided them into the control group and the treatment group randomly，45 cases in each group.Both groups were given routine intervention，and the control group was given oral donepezil hydrochloride tablets，while the treatment group additionally receivedmodified Ditan tang based on the treatment of the control group.The treatment of the two groups continuously lasted for 12 weeks.Compared scores of mini-mentalstate examination(MMSE)of Folstein，activity of daily living scale(ADL)and symptoms of syndrome of orifices confused by phlegm，levels of serum homocysteine(Hcy)and endothelin(ET)of patients as well as the post-treatment clinical effect before and after treatment.ResultsAfter treatment，the total effective rate was 91.11%in the treatment group，being higher than 71.11%in the control group，the difference being significant(P＜0.05).Scores of ADL and MMSE were increased when compared with those before treatment， while symptom scores of syndrome of orifices confused by phlegm were decreased，differences being significant(P＜0.01).Scores of ADL and MMSE in the treatment group were higher than those in the control group，while symptom scores of syndrome of orifices confused by phlegm were lower，differences being significant(P ＜0.01).Levels of serum Hcy and ET in both groups were decreased when compared with those before treatment(P＜0.01)，while levels of those two indexes in the treatment group were lower than those in the control group(P＜ 0.01).Conclusion：The therapy of modified Ditan tang combined with conventional western medicine therapy can obviously improve the living ability and cognitive function of patients with vascular dementia as well as the clinical efficacy，whose effect is superior to simple western medicine intervention.The mechanism may be through improving the neurotoxicity and promoting the brain blood circulation，so as to promote the recovery of patients.