Objective：To discuss the hypoglycemic effect of Shiyiwei Yishen Jiangtang prescription on rats with type 2 diabetes(NIDDM)and its effect on expression of Wnt/β-catenin signal pathway in kidney.Methods： High-glucose and high-fat diet combined with injection of streptozotocin(STZ)was applied to establish NIDDM model rats.Divided 60 SD rats into 6 groups randomly，namely the normal control group，model group，dapagliflozin group，Shiyiwei Yishen Jiangtang prescription of low，middle and high dose groups，10 rats in each group.Dapagliflozin group was given dapagliflozin tablets 1 mg/(kg·d)by gavage，Shiyiwei Yishen Jiangtang prescription of low，middle and high dose groups were given Shiyiwei Yishen Jiangtang prescription of 2，4，16 g/(kg·d)respectively by gavage，and the normal control group and model group were given equivalent normal saline by gavage，once a day，for 7 weeks successively.Measured the levels of fasting blood glucose(FBG)，glycosylated hemoglobin(HbA1c)and fasting insulin(FINS)of rats，and calculated insulin resistance index(IRI).Western blot was induced to detect the expression of Wnt4 and β-catenin protein.Results： Comparing with those in the normal control group，the levels of FBG、HbA1c and FINS were increased，IRI was increased and the expression of Wnt4 and β-catenin protein was both significantly increased in the model group，differences being significant(P＜ 0.05).After administration，comparing with those in the model group，the levels of FBG、HbA1c and FINS were distinctively decreased，IRI was significantly reduced and the expression of Wnt4 and β-catenin protein was both evidently decreased in dapagliflozin group and Shiyiwei Yishen Jiangtang prescription of middle and high dose groups，differences being significant(P＜0.05).Comparing with those before administration，the levels of FBG were distinctively decreased in dapagliflozin group and high-dose Shiyiwei Yishen Jiangtang prescription group，differences being significant(P＜0.05).Comparing with those before administration，the levels of HbA1c and FINS were distinctively decreased，IRI was significantly reduced in dapagliflozin group and Shiyiwei Yishen Jiangtang prescription of middle and high dose groups，differences being significant(P＜ 0.05).Conclusion：Shiyiwei Yishen Jiangtang prescription can effectively control the levels of FBG in rats with type 2 diabetes，adjust glucose metabolism，and inhabit the high expression of Wnt/β-catenin signal pathway in the kidney of NIDDM rats.