ObjectiveTo evaluate the clinical effectiveness of qi-tonifying and blood-activating therapy for idiopathic pulmonary fibrosis.MethodsBased on the retrieval of China National Knowledge Infrastructure(CNKI)，VIP，and Wanfang Database，literatures of clinical randomized controlled trials(RCT)about qi-tonifying and blood-activating therapy for idiopathic pulmonary fibrosis from 2001 to 2015 were selected.The quality of selected literatures was evaluated by modified Jadad scale，and the meta-analysis was conducted via Rev Man 5.3 software.ResultsSeven pieces of literature including 169 cases were brought into the meta-analysis.Resultsshowed that the difference was found in qi-tonifying and blood-activating therapy group and western medicine group for idiopathic pulmonary fibrosis in terms of clinical effective rate(combined odds ratio[OR]，3.08；95%confidence interval[CI]，1.91 to 4.96)，the difference being significant(P ＜ 0.01).From the perspective of the improvement of oxygen partial pressure，the sauter mean diameter was 3.27(95%CI，1.41 to 5.13).The results indicated that qi-tonifying and blood-activating therapy group was superior to western medicine group(P＜0.01).ConclusionQi-tonifying and blood-activating therapy is effective in treating idiopathic pulmonary fibrosis，which is superior to western medicine group in terms of clinical effective rate and the improvement of oxygen partial pressure.