ObjectiveTo observe the clinical effect of acupuncture combined with mecobalamin tablets for diabetic peripheral neuropathy.MethodsDivided 76 patients with diabetic peripheral neuropathy into the observation group and the control group randomly， 38 cases in each group.Both groups receivedmecobalamin tablets for treatment， while the observation group additionally received acupuncture.Evaluated the curative effect and observed changes of clinical symptoms and body signs，motor nerve conduction velocity(MCV)and sensory nerve conduction velocity(SCV)of patients before and after treatment.ResultsThe total effective rate was 94.74%in the observation group and was 76.32%in the control group，the difference being significant(P ＜ 0.05).After treatment，MCV and SCV in both groups were improved when compared withthose before treatment(P＜0.05).MCV and SCV in the observation group were faster than those in the control group(P＜0.05).After treatment，scores of Toronto clinical scoring sytem(TCSS)in both group were decreased when compared with those before treatment(P＜0.05).TCSS in the observation group were lower than those in the control group(P＜0.05).ConclusionAcupuncture combined with mecobalamin tablets can effectively improve symptoms and body signs of patients in treating diabetic peripheral neuropathy，and its effect is better than applying mecobalamin tablets only.