Objective：To observe the clinical effect of Huaiqihuang granules combined with prednisone acetate tablets for children nephrotic syndrome of qi-yin deficiency type.MethodsDivided 70 cases of children with nephrotic syndrome of qi-yin deficiency type into the control group and the observation group randomly，35 cases in each group.Both groups receivedprednisone acetate tablets for treatment，while the observation group additionally received Huaiqihuang granules.Both groups received treatment for 4 weeks.After treatment，evaluated the curative effect and observed changes of all indexes of immune function before and after treatment of children in both groups.ResultsThe total effective rate was 94.29% in the observation group and was 77.14% in the control group，the difference being significant(P＜0.05).After treatment，levels of IgG and IgA in the observation group were increased when compared with those before treatment and higher than those in the control group in the same period，differences being significant(P＜0.05).Compared levels of IgG，IgA and IgM in the control group and IgM levels in the observation group before and after treatment，there was no significance in differences(P＞0.05).After treatment，CD4+levels and CD4+/CD8+value in the observation group were increased when compared with those before treatment and higher than those in the control group in the same period，differences being significant(P＜0.05).Compared CD8+levels in both groups and CD4+levels，CD4+/CD8+value in the control group before and after treatment， there was no significance in differences(P＞0.05).ConclusionHuaiqihuang granules combined with prednisone acetate tablets has significant effect in treating children nephrotic syndrome of qi-yin deficiency type，which can effectively relieve clinical symptom and improve immune function of children.