ObjectiveTo observe the clinical effect of Qingfei Sanjie tang combined with Puji Xiaodu yin for adenoid hypertrophy in children.MethodsSelected 93 cases of children with adenoid hypertrophy，and divided them into the control group being 46 cases and the observation group being 47 cases randomly.Both groups receivedtreatment of single herbal concentrate-granules of Qingfei Sanjie tang，while the observation group additionally received Puji Xiaodu yin.Treatment of both groups lasted 15 days.Evaluated the clinical effect，recorded the disappearance time of symptoms in both groups such as snoring，nasal obstruction，mouth breathing and tinnitus，compared the volume of adenoid after treatment with those before treatment in the two groups， and statistically analyzed the adverse reactions in both groups.ResultsThe total effective rate was 91.49%in the observation group and 76.09%in the control group，the difference being significant(P＜0.05).The disappearance time of symptoms including snoring， nasal obstruction， mouth breathing and tinnitus in the observation group was all shorter than that in the control group，difference being significant(P ＜ 0.05).Before treatment，the volume of adenoid of both group were compared，difference being insignificant(P ＞ 0.05).After treatment，the volume of adenoid in both groups was smaller than that before treatment(P ＜ 0.05)；the volume of adenoid in the observation group was smaller than that in the control group(P＜0.05).Incidence of adverse reaction was 10.64%in the observation group and 6.52%in the control group，the difference being not significant(P＞0.05).ConclusionQingfei Sanjie tang combined with Puji Xiaodu yin has significant effect in the treatment of adenoid hypertrophy in children，and it can release the symptoms of children patients as well as improve symptoms with high safety.