ObjectiveTo observe the clinical effect and safety of Xiyanping injection for rotavirus enteritis.MethodsSelected 180 cases of patients with rotavirus enteritis，and divided them randomly into the control group and the treatment group，90 cases in each group.The control group was given the treatment of correcting the balance of water-electrdyte and acid-base，fluid infusion and other conventional treatment，while the treatment group was given Xiyanping injection based on the treatment of the control group.Evaluated the curative effect of the two groups and recorded the relief time of symptoms and signs.Observed the changes of creatine kinase(CK)，immune function index(IgA，IgG)，alanine aminotransferase(ALT)and serum creatinine(SCr)before and after treatment，and then recorded the incidence of adverse reaction.ResultsThe total effective rate was 75.6%in the control group and was 91.1%in the treatment group，the difference being significant(P＜0.01).The time of fever，vomiting，diarrhea，abdominal distention and pain，dehydration，and virus clearance time as well as hospitalization days in the treatment group were all shorter than those in the control group，differences being significant(P ＜ 0.05).After treatment，CK levels in both groups were decreased when compared with those before treatment，while levels of IgA and IgG were evidently increased(P＜0.05).CK levels in the treatment group were lower than those in the control group，while levels of IgA，IgG were higher than those in the control group，differences being significant(P ＜ 0.05).Comparisons of levels of ALT and SCr between the two groups before and after treatment showed no significance in differences(P＞0.05).ConclusionThe therapy of additional Xiyanping injection based on the conventional treatment can improve the curative effect for rotavirus enteritis，enhance the immune function and shorten the hospitalization time.During medication，the therapy did no adverse reaction has been found.