慢性肾衰竭周围神经病变中医证型与神经电生理关系研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R692.5

基金项目:

湿州市科技计划局项目(Y20160212)


Study on the Relationship of Chinese Syndrome Type with Nerve Electrophysiology in Chronic Renal Failure Patients with Peripheral Neuropathy
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:分析慢性肾衰竭周围神经病变不同中医证型患者的神经电生理相关指标,初步探讨各证型与神经电生理之间的关系,以期为中医辨证分型提供有参考价值的客观量化指标。方法:将纳入的80例慢性肾衰竭周围神经病变患者依据中医辨证标准分为脾肾气虚型、湿浊型、血瘀型、脾肾阳虚型各20例。所有患者采用肌电图仪进行神经电生理检查,分别检测正中神经、尺神经、胫神经、腓神经的运动神经传导速度(MCV)、复合肌肉动作电位(CMAP)波幅,正中神经、尺神经、腓浅神经的感觉神经传导速度(SCV)、感觉神经动作电位(SNAP)波幅。结果:4组发病年龄比较,差异无统计学意义(P>0.05)。4组病程比较,差异有统计学意义(P<0.05);脾肾阳虚组病程最长,与其余3组比较,差异均有统计学意义(P<0.05)。脾肾气虚组正中神经、尺神经、胫神经及腓神经的MCV均高于脾肾阳虚组、湿浊组、血瘀组(P<0.05);脾肾阳虚组正中神经、尺神经、胫神经及腓神经的MCV均低于脾肾气虚组、血瘀组、湿浊组(P<0.05)。脾肾气虚组正中神经、尺神经、腓浅神经的SCV均高于湿浊组、血瘀组、脾肾阳虚组(P<0.05);脾肾阳虚组正中神经、尺神经、腓浅神经的SCV均低于血瘀组、湿浊组、脾肾气虚组(P<0.05)。脾肾阳虚组CMAP波幅减小程度最大,脾肾气虚组减少程度最小。脾肾气虚组正中神经、尺神经、胫神经的CMAP波幅均高于脾肾阳虚组、湿浊组、血瘀组(P<0.05);脾肾阳虚组正中神经、尺神经、胫神经的CMAP波幅均低于脾肾气虚组、湿浊组、血瘀组(P<0.05);湿浊组腓神经CMAP波幅高于血瘀组(P<0.05)。脾肾气虚组SNAP波幅减少程度最小;脾肾气虚组正中神经、尺神经及腓浅神经SNAP波幅均高于脾肾阳虚组、血瘀组、湿浊组(P<0.05)。结论:慢性肾衰竭周围神经病变不同中医证型患者的神经电生理检查存在统计学差异,神经电生理是观察周围神经病变的敏感指标,可作为该疾病中医分型研究和干预治疗的客观参考指标之一。

    Abstract:

    Objective:To analyse the nerve electrophysiological index of patients with chronic renal failure of peripheral neuropathy and different types of Chinese medicine syndrome,and to make a preliminary discussion on the relationship of Chinese medicine syndrome type with nerve electrophysiology so as to provide the objective quantitative index of reference value for Chinese medicine syndrome differentiation.MethodsEighty cases of patients with chronic renal failure of peripheral neuropathy were divided into spleen-kidney qi deficiency type,dampness turbidity type,blood stasis type and spleen-kidney yang deficiency type based on the standards of Chinese medicine syndrome differentiation,each type being 20 cases respectively.All the patients receivedthe nerve electrophysiological examination via electromyography so as to detect the motor nerve conduction velocity(MCV)of median nerve,ulnar nerve,tibial nerve and peroneal nerve,amplitude of compound muscle action potential(CMAP), sensory nerve conduction velocity(SCV)of median nerve, ulnar nerve, tibial nerve and superficial peroneal nerve, amplitude of sensory nerve action potential(SNAP).ResultsOnset ages of 4 groups were compared,there was no significant difference(P> 0.05).Courses of 4 groups were compared,differences being significant(P < 0.05);the course of the spleen-kidney yang deficiency group was the longest,comparing with the other 3 groups,differences being significant(P < 0.05).MCV of median nerve,ulnar nerve,tibial nerve and peroneal nerve of the spleenkidney qi deficiency group was all higher than that of the spleen-kidney yang deficiency group,dampness turbidity group and blood stasis group(P < 0.05);MCV of median nerve,ulnar nerve,tibial nerve and peroneal nerve of the spleen-kidney yang deficiency group was all lower than that of the spleen-kidney qi deficiency group,blood stasis group and dampness turbidity group(P<0.05).SCV of median nerve,ulnar nerve and superficial peroneal nerve of the spleen-kidney qi deficiency group was all higher than that of the dampness turbidity group,blood stasis group and spleen-kidney yang deficiency group(P<0.05);SCV of median nerve,ulnar nerve and superficial peroneal nerve of the spleen-kidney yang deficiency group was all lower than that of the blood stasis group,dampness turbidity group and spleen-kidney qi deficiency group(P<0.05).The decrease degree of CMAP amplitude of the spleen-kidney yang deficiency group was the most significant,while that of the spleen-kidney qi deficiency group was the most slightest.CMAP amplitude of median nerve,ulnar nerve and peroneal nerve of the spleen-kidney qi deficiency group was all higher than that of the spleen-kidney yang deficiency group,dampness turbidity group and blood stasis group(P < 0.05);CMAP amplitude of median nerve,ulnar nerve and peroneal nerve of the spleen-kidney yang deficiency group was all lower than that of the spleen-kidney qi deficiency group,dampness turbidity group and blood stasis group(P < 0.05);CMAP amplitude of peroneal nerve of the dampness turbidity group was higher than that of the blood stasis group(P<0.05).The decrease degree of SNAP amplitude of the spleen-kidney qi deficiency group was the slightest;SNAP amplitude of median nerve,ulnar nerve and superficial peroneal nerve of the spleen-kidney qi deficiency group was all higher than that of the spleen-kidney yang deficiency group,blood stasis group and dampness turbidity group(P<0.05).ConclusionThere are differences in the nerve electrophysiological examination of patients with chronic renal failure of peripheral neuropathy and different types of Chinese medicine syndrome.Nerve electrophysiology is a sensitive index for observing peripheral neuropathy,and can be one of the objective quantitative indexes of reference value for Chinese medicine syndrome differentiation study and interventional treatment.

    参考文献
    相似文献
    引证文献
引用本文

邵思思,项协隆,陈春,任丽雯,黄建平,董飞侠,黄蔚霞.慢性肾衰竭周围神经病变中医证型与神经电生理关系研究[J].新中医,2018,50(2):39-43

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2018-02-08
  • 出版日期: