Objective：To observe the clinical effect of Qingre Huashi tang combined with western medicine for treating peptic ulcer with dampness heat in spleen and stomach.MethodsSelected 114 cases of patients with helicobacter pylori positive peptic ulcer with dampness heat in spleen and stomach based on syndrome differentiation，and divided them into the control group and the observation group randomly，57 cases in each group.The control group was firstly given triple therapy of anti-helicobacter pylori with esomeprazole magnesium enteric-coated tablets， clarithromycin tablets， and ampicillin capsules for 2 weeks， then given pantoprazole sodium enteric-coated tablets therapy for another 2 weeks， while the observation group was additionally receivedQingre Huashi tang everyday based on the treatment of the control group for 4 weeks.Treatment for both groups lasted for four weeks.Scored the Chinese medicine symptoms and gastric and duodenal mucosal injuries of two groups，and evaluated clinical curative effect of patients in both groups.ResultsAfter treatment，the total effective rate in the observation group was higher than that in the control group，the difference being significant(P＜0.01).The scores of epigastric burning pain，gastric upset and discomfort，dry mouth and bitter taste，dementia and nausea，sweet taste and sticky mouth，and heavy body and tired limbs as well as the gastric and duodenal mucosal injury scores in two groups were lower than those before treatment，difference beings significant(P ＜ 0.05).The scores of Chinese medicine symptoms and the gastric and duodenal mucosal injury scores in the observation group were both lower than those in the control group，differences being significant(P ＜ 0.05).ConclusionQingre Huashi tang combined with western medicine for peptic ulcer with dampness heat in spleen and stomach can effectively improve the clinical symptoms of patients，help to promote mucosal recovery and clinical curative effect.