ObjectiveTo observe the clinical effect of Suhuang Zhike capsules combined with azithromycin for cough variant asthma(CVA).MethodsDivided 92 CVA patients with wind pathogen invading lung syndrome into the observation group and the control group randomly according to random number table method，46 cases in each group.Both groups receivedprocaterol， ketotifen and azithromycin for treatment， while the observation group additionally received Suhuang Zhike capsules.The course of treatment for both groups lasted for 4 weeks.Observed changes of cough scores and levels of inflammatory mediators interleukin-6(IL-6)，tumor necrosis factor- α (TNF-α)，serum immunoglobulin E(IgE)and eosinophil(EOS)of patients in both groups before and after treatment.Evaluated clinical effect of patients in both groups.ResultsAfter treatment，the total effective rate was 93.48%in the observation group，higher than 71.74%in the control group，the difference being significant(P＜ 0.01).Scores of cough character，cough degree and cough times in both groups were decreased when compared with those before treatment(P ＜ 0.05)；above three scores in the observation group were lower than those in the control group，differences being significant(P＜0.05).Levels of IL-6，TNF-α，IgE and EOS in both groups were decreased when compared with those before treatment(P＜ 0.05)；levels of above four indexes in the observation group were lower than those in the control group(P＜0.05).ConclusionSuhuang Zhike capsules combined with azithromycin on the basis of routine therapy can effectively improve clinical symptoms of CVA patients with wind pathogen invading lung syndrome，relieve inflammatory reaction and enhance immune function of patients.