ObjectiveTo observe the effect of Buyang Huanwu tang on blood lipid and inflammatory factors of atherosclerosis plaque such as lipoprotein-associated phospholipase A2(Lp-PLA2)and matrix metalloproteinase-9(MMP-9)in apoe gene-deficient(ApoE-/-)mice.MethodsThirty-four ApoE-/-mice were fed with high-fat diet for 12 weeks.Randomly selected 4 of them to determine success of the models.After establishing successful models，divided the rest 30 mice into the model group，Buyang Huanwu tang group，and atorvastatin group randomly according to random number table，10 mice in each group.Buyang Huanwu tang group was given 20 g/(kg·d)of Buyang Huanwu tang by gavageand，atorvastatin group was given 5 mg/(kg·d)of atorvastatin by gavage.The model group was given equivalent amount of saline.After 4 weeks of medication， measured the blood lipid level， and detected levels of Lp-PLA2 and MMP-9 in serum with ELISA method.ResultsCompared with those in the model group，in Buyang Huanwu tang group and atorvastatin group，levels of totalcholesterol(TC)， triglyceride(TG)， and low density lipoprotein cholesterol(LDL-C)of mice were all decreased， levels of high-density lipoprotein cholesterol(HDL-C)were increased，and levels of Lp-PLA2 and MMP-9 in serum were obviously reduced，differences being significant(P ＜ 0.05).Compared the levels of TC，TG，LDL-C，HDL-C，Lp-PLA2，and MMP-9 in Buyang Huanwu tang group with those in atorvastatin group，there was no significance being found in differences(P＞0.05).ConclusionBuyang Huanwu tang has an anti-atherosclerosis effect，and one of its mechanism may be the function of lowering blood lipid and reducing inflammatory reaction.