Objective： To observe the clinical effect of press-needle co mbined with Huanglian Ejiao tang for perimenopause insomnia of kidney deficiency and liver depression type.Methods：Divided 120 patients with perimenopause insomnia of kidney deficiency and liver depression type into press-needle combined with medicine group，Chinese medicine group and western medicine group randomly，40 cases in each group.The press-needle combined with medicine group was given press-needle combined with Huanglian Ejiao tang,Chinese medicine group was given Huanglian Ejiao tang，The western medicine group was given estazolam tablets.Evaluated the curative effect in three groups，observed changes of insomnia severity index(ISI)scores of patients before and after treatment and recorded the incidence of Chinese medicine symptoms.Results：The total effective rate was 90.0%in acupuncture combined with medicine group，67.5%in Chinese medicine group and 82.5%in western medicine group.The total effective rate in acupuncture combined with medicine group was higher than that in Chinese medicine group(P＜0.05)，the total effective rate in acupuncture combined with medicine group was similar to that in western medicine group(P＞0.05).After treatment，scores of difficulty getting asleep，sleep maintenance difficult and early awakening，as well as ISI total scores in the three groups were lower than those before treatment(P＜0.01).ISI total scores in acupuncture combined with medicine group were higher than those in Chinese medicine group and western medicine group after treatment(P＜0.01).There was no significant difference being found in the difference value of ISI total scores in western medicine group and Chinese medicine group before and after treatment(P＞0.05).The difference value of scores of difficulty getting asleep，and sleep maintenance difficult in acupuncture combined with medicine group before andafter treatment was higher than those in western medicine group and Chinese medicine group(P＜0.01).The difference value of scores of difficulty getting asleep and sleep maintenance in western medicine group before and after treatment were higher than those in Chinese medicine group(P＜0.05).The difference value of scores of early awakening index in acupuncture combined with medicine group before and after treatment was higher than that in Chinese medicine group(P＜0.05).Compared the difference of scores of early awakening index before and after treatment in western medicine group with those in Chinese medicine group or in acupuncture combined with medicine group，there was no significance in the difference(P＞0.05).After treatment，the incidences of depression，sigh oftenly，hectic fever and sweating，dysphoria and irritation，and burning sensation of five centers in acupuncture combined with medicine group and Chinese medicine group were lower than those before treatment(P＜0.05)，and lower than those in western medicine group(P＜0.05).The incidences of depression as well as dysphoria and irritation in acupuncture combined with medicine group were lower than those in Chinese medicine group(P＜0.05).Conclusion：Press-needle combined with Huanglian Ejiao tang has significant effect in treating perimenopause insomnia of kidney deficiency and liver depression type，which can effectively improve sleep quality of patients.