Objective： To observe the clinical effect of the prescription of tonifying lung and kidney combined with resolving stasis and detoxification combined with endocrine therapy for castrated resistant prostate cancer.Methods：Divided 72 cases of patients with castrated resistant prostate cancer according with the inclusion criteria into the control group and the treatment group randomly.Both groups receivedwestern medicine therapy of maximal androgen blockade(MAB)，while the treatment group additionally received the prescription of tonifying lung and kidney combined with resolving stasis and detoxification.The course of treatment for both groups lasted for 3 months.Observed changes of overall survival，serum prostate specific antigen(PSA)，physical status，life quality and Chinese medicine symptom scores before and after treatment in both groups.Results： After treatment， in the control group， serum PSA levels were increased obviously， scores of Karnofsky and each aspect of life quality were decreased，as well as Chinese medicine symptom scores were increased，compared with those before treatment，differences being significant(P＜0.05).Serum PSA levels in the treatment group were not significantly increased，comparing with those before treatment，there was no significance in differences(P＞0.05).Serum PSA levels in the treatment group were lower than those in the control group，the difference being significant(P＜0.05).Karnofsky scores were increased obviously，scores of each aspect of life quality were improved，and Chinese medicine symptom scores in the treatment group were decreased， comparing with those before treatment， differences being significant(P＜0.05).The comparisons of the above scores between the two groups showed significance in differences(P＜0.05).The number of death cases was 13 and the average survival was 24.1 months in the treatment group，while the number of death cases was 15 and the average survival was 19.7 months in the control group.Conclusion：Chinese medicine therapy of tonifying lung and kidney prescription as well as resolving stasis and detoxification prescription for castrated resistant prostate cancer can reduce side effect of western medicine therapy，stabilize PSA level and improve life quality of patients so as to prolong overall survival of patients.