化痰活血方穴位贴敷治疗强直性脊柱炎临床研究
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R593.23

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Clinical Study of Point Application with Huatan Huoxue Prescription for Ankylosing Spondylitis
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    摘要:

    目的:观察化痰活血方穴位贴敷治疗痰瘀阻络型强直性脊柱炎的临床疗效。方法:选取符合纳入标准的痰瘀阻络型强直性脊柱炎(AS)患者100例,随机分为2组各50例。对照组采用常规西药治疗,观察组在对照组治疗方案的基础上给予化痰活血方穴位贴敷治疗。比较治疗前后2组患者疼痛视觉模拟评分量表(VAS)评分、强直性脊柱炎病情活动指数(BASDAI)、巴氏强直性脊柱炎功能指数(BASFI)、红细胞沉降率(ESR)、C-反应蛋白(CRP)等指标的差异,采用中医证候评分量表对效果进行评估,并观察治疗前后2组肝功能、肾功能及血液常规情况,了解2组患者的机体功能情况。结果:2组的临床疗效比较,总有效率观察组80.0%,对照组46.0%,差异有统计学意义(P<0.05)。治疗后,2组各项指标的疼痛VAS评分、BASDAI、BASFI、ESR、CRP治疗前后比较,差异均有统计学意义(P<0.05);2组各指标组间比较,差异均有统计学意义(P<0.05)。2组晨僵时间、脊背活动不利、舌苔厚腻、痰多吐涎、舌质暗紫舌下脉络迂曲、腰骶脊背疼痛、脉弦滑、总积分等中医证候积分组间比较,差异均有统计学意义(P<0.05)。2组以上各项评分分别与治疗前比较,差异均有统计学意义(P<0.05)。2组患者在治疗时,有5例观察组患者皮肤出现小水泡,因为未发生严重的感染和溃烂,且针对处理后快速消失,不列入不良反应。同时,2组肝功能谷草转氨酶(AST)、谷丙转氨酶(ALT),肾功能肌酐(Cr)、尿素(Urea)与治疗前比较,差异无统计学意义(P>0.05),2组以上各项指标治疗后比较,差异无统计学意义(P>0.05)。结论:化痰活血方穴位贴敷治疗痰瘀阻络型强直性脊柱炎患者有明显疗效,可以缓解患者疼痛,改善其生活状况。

    Abstract:

    Objective:To observe the clinical effect of point application with Huatan Huoxue prescription for ankylosing spondylitis(AS)of phlegm-stasis and collaterals-blocking type.Methods:Selected 100 cases of patients with AS of phlegm-stasis blocking collaterals type according to the inclusion criteria,and divided them into two groups randomly,50 cases in each group.The control group receivedroutine western medicine,while the observation group was given Huatan Huoxue prescription with point application based on the treatment of the control group.Compared the differences among visual analog scale(VAS)pain score,bath ankylosing spondylitis disease activity index(BASDAI),bath ankylosing spondylitis functional index(BASFI), erythrocyte sedimentation rate(ESR), C Reactive protein(CRP)and other indexes in both groups before and after treatment.Evaluated the effect by Chinese medicine syndrome score scale,observed the liver function,renal function and blood routine,and studied the body function of patients in both groups.Results:When compared the clinical effect of both groups,the total effective rate was 80.0% in the observation group and was 46.0%in the control group,the difference being significant(P< 0.05).After treatment,compared VAS pain score,BASDAI,BASFI,ESR and CRP of the two groups,the difference showed significance(P<0.05).The comparison of each index between two groups showed significance in differences(P< 0.05).When compared time of morning stiffness,inflexible spine and back movement,thick and greasy tongue coating,excessive phlegm and peysis,dark purple tongue body,and tortuous sublingual venae,lumbosacral spine and back pain,wiry and slippery pulse,and total scores of Chinese medicine syndrome between two groups,differences were significance(P<0.05).When compared each score above in both group with that before treatment respectively,differences were significant(P< 0.05).During treatment of two groups,blisters appeared on the skin of five patients.There was no serious infection and ulceration,and the symptoms disappeared rapidly after treatment,so they were not included in adverse reactions.At the same time,compared Aspartate aminotransferase(AST)and Alanine aminotransferase(ALT)of liver function,the Creatinine(Cr)and Blood urea nitrogen(BUN)of renal function of both groups with those before treatment,differences were not significant(P > 0.05);there was no significant difference being found in the comparison of each index above in two groups(P>0.05).Conclusion:Point application with Huatan Huoxue prescription has an significant curative effect on patients with AS of phlegm-stasis and collaterals-blocking type,which can relieves pain and improves living condition of patients.

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侯丰枝.化痰活血方穴位贴敷治疗强直性脊柱炎临床研究[J].新中医,2018,50(1):81-84

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  • 在线发布日期: 2018-01-05
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