Objective：To observe the clinical effect of point application with Huatan Huoxue prescription for ankylosing spondylitis(AS)of phlegm-stasis and collaterals-blocking type.Methods：Selected 100 cases of patients with AS of phlegm-stasis blocking collaterals type according to the inclusion criteria，and divided them into two groups randomly，50 cases in each group.The control group receivedroutine western medicine，while the observation group was given Huatan Huoxue prescription with point application based on the treatment of the control group.Compared the differences among visual analog scale(VAS)pain score，bath ankylosing spondylitis disease activity index(BASDAI)，bath ankylosing spondylitis functional index(BASFI)， erythrocyte sedimentation rate(ESR)， C Reactive protein(CRP)and other indexes in both groups before and after treatment.Evaluated the effect by Chinese medicine syndrome score scale，observed the liver function，renal function and blood routine，and studied the body function of patients in both groups.Results：When compared the clinical effect of both groups，the total effective rate was 80.0% in the observation group and was 46.0%in the control group，the difference being significant(P＜ 0.05).After treatment，compared VAS pain score，BASDAI，BASFI，ESR and CRP of the two groups，the difference showed significance(P＜0.05).The comparison of each index between two groups showed significance in differences(P＜ 0.05).When compared time of morning stiffness，inflexible spine and back movement，thick and greasy tongue coating，excessive phlegm and peysis，dark purple tongue body，and tortuous sublingual venae，lumbosacral spine and back pain，wiry and slippery pulse，and total scores of Chinese medicine syndrome between two groups，differences were significance(P＜0.05).When compared each score above in both group with that before treatment respectively，differences were significant(P＜ 0.05).During treatment of two groups，blisters appeared on the skin of five patients.There was no serious infection and ulceration，and the symptoms disappeared rapidly after treatment，so they were not included in adverse reactions.At the same time，compared Aspartate aminotransferase(AST)and Alanine aminotransferase(ALT)of liver function，the Creatinine(Cr)and Blood urea nitrogen(BUN)of renal function of both groups with those before treatment，differences were not significant(P ＞ 0.05)；there was no significant difference being found in the comparison of each index above in two groups(P＞0.05).Conclusion：Point application with Huatan Huoxue prescription has an significant curative effect on patients with AS of phlegm-stasis and collaterals-blocking type，which can relieves pain and improves living condition of patients.