Objective：To observe the effect of oral administration of Yiqi Ziyin Huoxue prescription on blood glucose，renal function， plasma Cystatin C(CysC)， and high sensitivity C-reactiveprotein(hs-CRP)in patientswith early diabetic nephropathy(DN).Methods：Selected 80 cases of patients with early DN，and divided them randomly into the treatment group and the control group， 40 cases in each group.Both groups were given diabetes diet， proper exercise， oral administration of hypoglycemic agents or insulin to control blood glucose.The control group was additionally given telmisartan tablets based on the mutual treatment，while the treatment group was additionally given Yiqi Ziyin Huoxue prescription based on the treatment of the control group.Observed changes of Chinese medicine symptom score， blood glucose， renal function， CysC and hs-CRP in both groups before and after treatment.Results： After treatment， Chinese medicine symptom scores of both groups were decreased when compared with those before treatment(P＜ 0.05)，and the scores of the treatment group were decreased more obviously than those of the control group(P＜ 0.05).After treatment，levels of fasting blood-glucose(FBG)， postprandial 2h plasma glucose(P2hBG)， urinary microalbumin(umAlb)， and serum creatinine(SCr)and urinary albumin excretion rate(UAER)in both groups were all decreased when compared with those before treatment(P＜0.05).Levels of FBG，P2hBG，umAlb，and SCr as well as UAER of the treatment group were decreased more obviously than those of the control group(P＜ 0.05).After treatment，CysC levels in both groups and hs-CRP levels in the treatment group were both decreased when compared with those before treatment(P＜ 0.05)，and levels of CysC and hs-CRP in the treatment group were lower than those in the control group(P＜0.05).There was no significant difference being found in the comparison of hs-CRP levels in the control group before and after treatment(P＞0.05).Conclusion：Yiqi Ziyin Huoxue prescription has a curative effect on early DN，which can effectively improve clinical symptoms and renal function，control blood glucose，and reduce inflammation of patients.