麻杏石甘汤加减治疗成人社区获得性肺炎痰热蕴肺证临床观察
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Clinical Observation of Modified Maxing Shigan Tang for Community Acquired Pneumonia in Adults with Phlegm-heat in Lung Syndrome
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    摘要:

    目的:观察麻杏石甘汤加减治疗成人社区获得性肺炎(CAP)痰热蕴肺证的临床疗效。方法:将110例成人CAP痰热蕴肺证患者纳入研究,按照随机数字表法分为对照组和观察组,每组55例。观察2组治疗前后C-反应蛋白(CRP)、中性粒细胞百分比(GR)、白细胞计数(WBC)及免疫球蛋白(IgG、IgA、IgM)、CD4+/CD8+的变化,记录主要症状的改善时间,对比2组治疗总有效率和不良反应发生率。结果:治疗后,2组CRP、GR、WBC水平均较治疗前降低(P<0.05);观察组以上3项指标水平均低于对照组(P<0.05)。治疗后,观察组IgG、IgA、IgM水平及CD4+/CD8+均较治疗前升高(P<0.05),且均高于对照组同期(P<0.05);对照组IgM水平与治疗前比较,差异无统计学意义(P>0.05)。观察组总有效率94.55%,对照组总有效率78.18%,2组比较,差异有统计学意义(P<0.05)。观察组咳嗽、咯痰、发热改善时间均短于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上加用麻杏石甘汤加减治疗成人CAP痰热蕴肺证,能降低患者的炎症因子水平,改善临床症状,增强免疫功能,提高治疗效果。

    Abstract:

    Objective: To observe the clinical curative effect of modified Maxing Shigan tang for community acquired pneumonia(CAP)in adults with phlegm-heat in lung syndrome.Methods:One hundred and ten cases of adults with CAP of phlegm-heat in lung syndrome were included in the study and were divided into the control group and the observation group according to the random number table method,55 cases in each group.Observed the changes of c-reactive protein(CRP),neutrophils granulocyte rate(GR),white Blood cell count(WBC),immunoglobulin(IgG,IgA,IgM),and CD4+/CD8+in both groups before and after treatment,recorded the disappearance time of main symptoms,and compared the total effective rate and incidence of adverse reaction in both groups.Results:After treatment,the levels of CRP,GR,and WBC in both groups were all reduced(P< 0.05);the three indexes in the observation group were all lower than those in the control group(P< 0.05).After treatment,the levels of IgG,IgA,and IgM and CD4+/CD8+in the observation group were higher than those before treatment and those in the control group in the same period(P<0.05).Compared IgM levels of the control group after treatment with that before treatment,the difference was not significant(P > 0.05).The total effective rate was 94.55%in the observation group and 78.18%in the control group,the difference being significant(P<0.05).The time for improvement of cough,expectoration and fever in the observation group were all shorter than those in the control group(P<0.05).There was no significant difference in incidence of adverse reaction between the two groups(P>0.05).Conclusion:Based on routine therapy,the additional application of Maxing Shigan tang for community acquired pneumonia in adults with phlegm-heat in lung syndrome can reduce level of inflammatory factor,improve clinical symptoms,strengthen the immune function,and develop the curative effect.

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戴乐凤.麻杏石甘汤加减治疗成人社区获得性肺炎痰热蕴肺证临床观察[J].新中医,2018,50(1):41-44

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  • 在线发布日期: 2018-01-05
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