Objective：To discuss the effect of curcumin pretreatment on rats with lung ischemia reperfusion injury.Methods：Divided 48 healthy adult male SD rats into sham operation group(group S)，ischemia reperfusion group(group IR)，low-concentration curcumin group(group C50)and high-concentration group(group C200)randomly，12 rats in each group.Group C50 and group C200 receiveddisposablel abdominal injection of curcumin(50 mg/kg and 200mg/kg respectively)2 h before anesthesia，occluding left pulmonary hilus for 60 min and reperfusing for 180 min.Group S received abdominal injection of equivalent saline 2 h before anesthesia，no occlusion of the left pulmonary hilus after opening chest，and was put aside for 240 min.Group IR received abdominal injection of equivalent saline 2 h before anesthesia，occluding leftpulmonary hilus for 60 min and reperfusing for 180 min.Before ischemia and in the 60th，120th and 180th min of reperfusion，collected the blood of right carotid artery to conduct a blood gas analysis，and calculated the respiratory index(RI).In the end of reperfusion，the rats were sacrificed for collecting the pulmonary tissue.Observed the pathological changes of the pulmonary tissue，measured wet-dry weight ratio(W/D)，detected the content of superoxide dismutase(SOD)and malondialdehyde(MDA).Results：Comparing with that before ischemia，RI of the group IR in each time point of reperfusion was significantly increased(P＜ 0.05).Comparing with that of group S，RI of the group IR in each time point of reperfusion was significantly increased，the content of MDA，W/D and scores of pulmonary injury were higher，while the activation of SOD was lower，differences being significant(P＜ 0.05).Comparing with that of group IR，RI of the group C50 and group C200 in each time point of reperfusion wassignificantly decreased，the content of MDA，W/D and scores of pulmonary injury were lower，while the activation of SOD washigher，differences being significant(P＜ 0.05).Comparing with that of group C50，RI of the group C200 in each time point of reperfusion was significantly decreased，the concentration of MDA，W/D and scores of pulmonary injury were lower，while the activation of SOD was higher，differences being significant(P＜ 0.05).Conclusion：Curcumin pretreatment can release lung ischemia reperfusion injury in a dose-dependent manner，and the mechanism may be relevant with its curcumin of releasing pulmonary edema，reducing the formation of oxidation products and enhancing the function of clearing oxygen free radicals.