射干麻黄汤治疗难治性哮喘meta分析
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R256.12

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国家自然科学基金项目(81673901)


Meta-Analysis on Shegan Mahuang Tang for Refractory Asthma
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    摘要:

    目的:系统评价射干麻黄汤治疗难治性哮喘的临床疗效和安全性。方法:选择The Cochrane Library、EMBASE、PubMed、中国期刊全文数据库(CNKI)、中国科技期刊全文数据库(VIP)和万方数据库(Wangfang)等数据库,计算机检索检索年限为建库至2017年9月间所有射干麻黄汤治疗难治性哮喘的随机对照文献,并追溯纳入研究的参考文献。由2名研究人员分别对检索出的文献进行筛选,提取有效数据,最后运用RevMan软件进行数据Meta分析。结果:共纳入8个临床随机对照试验,563例患者。Meta分析结果显示:在西药基础上应用射干麻黄汤较单纯应用西药治疗,可提高患者临床总有效率,提高患者1秒用力呼气容积,改善患者哮喘控制测试评分,差异均有临床意义。结论:射干麻黄汤能改善难治性哮喘患者临床总有效率、1秒用力呼气容积以及哮喘控制测试评分,但本次分析受纳入研究的数量和质量的限制,其结果仍需进一步更严格的、多中心、大样本的随机双盲对照试验加以验证。

    Abstract:

    Objective: To systematically evaluate the clinical effect and safety of Shegan Mahuang tang treating refractory asthma.Methods:Databases such as the Cochrane Library,EMBASE,PubMed,Chinese Periodical Full-Text Database(CNKI),Chinese Sci-Tech Periodical Full-Text Database(VIP),and Wanfang Database(wanfang)were selected for the analysis.Literature of randomized controlled trials in treating refractory asthma with Shegan Mahuang tang was retrieved from the time of database establishment to September,2017 on the computer.References included in the study were searched as well.Two researchers were responsible for the screening of retrieved literature as well as the extraction of valid data.The meta-analysis was eventually conducted via RevMan software.Results:Eight randomized clinical controlled trials including 563 cases of patients were brought into the meta-analysis.Results showed that the additional application of Shegan Mahuang tang based on western medicine,compared with the simple application of western medicine therapy,could increase the total effective rate and the forced expiratory volume in one second(FEV1)of clinical patients,and could improve asthma control test scores of patients,differences being significant.Conclusion:Shegan Mahuang tang can improve the total effective rate,FEV1and asthma control testscores ofpatients.Nevertheless,with the limitation of the quantity and quality of the studies being included in the analysis,the results still need to be further verified by a stricter,multicenter and large-sampled randomized double-blind trial.

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蔡书宾,张忠德.射干麻黄汤治疗难治性哮喘meta分析[J].新中医,2017,49(12):159-162

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  • 在线发布日期: 2017-12-02
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