参芪扶正注射液联合化疗对弥漫大B细胞淋巴瘤患者造血功能及免疫功能的影响
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R733.4

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永康市科技计划项目(201629)


Effect of Shenqi Fuzheng Injection Combined with Chemotherapy on Hematopoietic and Immune Function of Patients with Diffuse Large B-cell Lymphoma
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    摘要:

    目的:观察参芪扶正注射液联合化疗对弥漫大B细胞淋巴瘤患者的临床疗效及其对造血功能、免疫功能影响。方法:将弥漫大B细胞淋巴瘤(肺脾气虚型)行化疗干预的80例患者随机分为2组各40例,对照组患者采用R-CHOP21方案化疗,观察组则在对照组治疗方案的基础上同时予参芪扶正注射液静脉滴注治疗,治疗21天为1周期,2组均持续4个化疗周期。比较2组临床疗效及患者免疫功能情况。结果:治疗后,2组CD4+、CD3+、CD4+/CD8+等指标均降低,前后比较,差异均有统计学意义(P<0.05)。治疗后,观察组各指标均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组IgA、IgG、IgM水平均降低,差异均有统计学意义(P<0.05);治疗后,观察组各项免疫球蛋白水平高于对照组,差异均有统计学意义(P<0.05)。2组临床疗效总有效率对照组85.0%,观察组92.5%,2组比较,差异无统计学意义(P>0.05)。2组白细胞减少、贫血、血小板减少等不良反应总发生率比较,差异均有统计学意义(P<0.05)。结论:参芪扶正注射液联合化疗治疗弥漫大B细胞淋巴瘤效果良好,可有效减轻化疗引起的骨髓抑制及免疫功能损伤。

    Abstract:

    Objective:To observe the clinical effect of Shenqi Fuzheng injection combined with chemotherapy for patientswith diffuse large B-cell lymphoma and its influence on hematopoietic and immune function.Methods:Divided 80 cases of patients with diffuse large B-cell lymphoma(lung-spleen qi deficiency type)intervened by chemotherapy into two groups randomly, 40 cases in each group.Both groups receivedR-CHOP21 chemotherapy,while the observation group additionally received intravenous drip of Shenqi Fuzheng injection,21 days as one course.Both groups received four chemotherapeutic courses.Compared the clinical effect as well as immune function between the two groups.Results:After treatment,indexes such as CD4+,CD3+and CD4+/CD8+in both groups were decreased,comparing with those before treatment,differences being significant(P < 0.05).After treatment,indexes in the observation group were all higher than those in the control group,differences being significant(P < 0.05).After treatment,levels of IgA,IgG and IgM were decreased,differences being significant(P < 0.05);after treatment,immunoglobulin levels in the observation group were higher than those in the control group,differences being significant(P<0.05).The total effective rate was 85.0%in the control group and 92.5%in the observation group,no significance being found in the difference(P>0.05).The total occurrence rate of adverse reaction such as leukopenia,anemia,thrombocytopenia was compared between the two groups,differences being significant(P < 0.05).Conclusion:Shenqi Fuzheng injection combined with chemotherapy has significant effect on treating diffuse large B-cell lymphoma,and it can effectively alleviate myelosuppression and immune function damage caused by chemotherapy.

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王妙玲,蒋志明,吕章春.参芪扶正注射液联合化疗对弥漫大B细胞淋巴瘤患者造血功能及免疫功能的影响[J].新中医,2017,49(12):122-125

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  • 在线发布日期: 2017-12-02
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