化痰活血法治疗痰瘀互结型原发性高血压病 84 例疗效观察
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R544.1

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河南省教育厅自然科学基础研究计划项目(2010A360003)


Observation of Huatan Huoxue Prescription Combined with Western Medicine for Primary Hypertension with Phlegm and Blood Stasis Type
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    摘要:

    目的:观察化痰活血方联合西药治疗痰瘀互结型原发性高血压的临床疗效。方法:将166例原发性高血压患者随机分为治疗组84例和对照组82例。2组均服用苯磺酸氨氯地平片、马来酸依那普利片治疗,治疗组加用化痰活血方,2组均治疗8周。观察2组患者治疗前后血压、心率、中医症状积分以及血脂水平的变化。结果:治疗后,治疗组总有效率92.86%,对照组总有效率89.02%,2组比较,差异无统计学意义(P>0.05)。治疗4周、8周,2组收缩压和舒张压均较治疗前下降(P<0.05);治疗8周,治疗组的收缩压低于对照组(P<0.05)。治疗8周后,治疗组心率较治疗前下降(P<0.05),并且低于对照组(P<0.05)。治疗组眩晕、头重如裹、心悸胸闷、呕吐痰涎、口淡纳差积分均较治疗前下降,差异均有统计学意义(P<0.05);而对照组仅眩晕积分与治疗前比较有统计学差异(P<0.05)。治疗组眩晕、头重如裹、心悸胸闷、呕吐痰涎、口淡纳差积分均低于对照组,差异均有统计学意义(P<0.05)。治疗组甘油三酯、总胆固醇及低密度脂蛋白胆固醇水平均较治疗前下降,高密度脂蛋白胆固醇较治疗前升高,差异均有统计学意义(P<0.05);而对照组治疗前后各指标均无明显改变,差异均无统计学意义(P>0.05);治疗组各指标与对照组比较,差异均有统计学意义(P<0.05)。结论:化痰活血方联合西药可明显改善痰瘀互结型原发性高血压患者的临床症状、血压、心率和血脂水平,且安全性较好。

    Abstract:

    Objective:To observe the clinical effect of Huatan Huoxue prescription combined with western medicine for primary hypertension with phlegm and blood stasis type.Methods:Divided 166 cases of patients with primary hypertension with phlegm and blood stasis type into the treatment group being 84 cases and the control group being 82 cases randomly.Both groups were given amlodipine besylate tablets and enalapril maleate tablets,while the treatment group additionally receivedHuatan Huoxue prescription.Treatment for both groups lasted for 8 weeks.Observed the changes of blood pressure,heart rate,score of Chinese medicine syndrome,and blood lipid level in both groups before and after treatment.Results:After treatment,the total effective rate was 92.86%in the treatment group and 89.02%in the control group,there being no significance in the difference(P > 0.05).Compared with those before treatment,systolic blood pressure and diastolic blood pressure in both groups were reduced in the 4th and 8th week of treatment(P < 0.05).After 8 weeks of treatment,systolic blood pressure and the heart rate in the treatment group were lower than those in the control group(P < 0.05),and the heart rate in the treatment group was lower than that before treatment(P < 0.05).After 8 weeks of treatment,the symptom scores of dizziness,heavy senation of the head,palpitation,chest distress,vomiting watery sputum,tastelessness and loss of appetite in the treatment group were all lower than those before treatment,differences being significant(P < 0.05),while in the control group only the symptom scores of dizziness was evidently reduced(P< 0.05).The symptom scores of dizziness,heavy senation of the head,palpitation and chest distress,vomiting watery sputum,tastelessness and loss of appetite in the treatment group were all lower than those in the control group(P < 0.05).After 8 weeks of treatment,the levels of triglyceride, total cholesterol, and low density lipoprotein cholesterol were reduced in comparison with those before treatment,and the levels of high-density lipoprotein cholesterol were higher than those before treatment(P < 0.05);there was no obvious change of the above indexes in the control group after treatment(P > 0.05);differences of the above indexes of the two groups were significant after treatment(P<0.05).Conclusion:Huatan Huoxue prescription combined with western medicine can obviously improve the clinical symptom,blood pressure,heart rate,and blood lipid level of the patients with hypertension with phlegm pattern,and there are no side effect and adverse reaction in the treatment group in this study.

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吴芳,丁黎琳,关徐涛,左新华.化痰活血法治疗痰瘀互结型原发性高血压病 84 例疗效观察[J].新中医,2017,49(12):17-20

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  • 在线发布日期: 2017-12-02
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