According to the theories of Chinese medicine，combined with the clinical insights，Professor GUO Zhouke believes that cerebral small vessel disease causes cognitive impairment，because phlegm-dampness retention and blood stasis stagnating orifices are induced by emotional upsets， protracted illnesses， lack of proper treatment or erroneous treatment on the basis of kidney-essence deficiency and internal consumption of essence and blood，which lasts so long that the brain marrowloses nourishment.Its pathogenic factors can be generalized as three aspects including“ deficiency，phlegm，stagnation”；its fundamental pathogenesis is marrow-sea deficiency and mental dysfunction.Clinically aiming at the pathogenesis of this disease，the method of invigorating qi and promoting blood as well as dispelling phlegmand opening orifices is applied，and the experienced prescription of Naosuikang ismade，which has good clinicaleffect.