Abstract： Objective： To observe the clinical effect of applying mind- regulating and constraintresolving acupuncture method combined with Xiaoxingnao acupuncture method for post- stroke with comorbid anxiety and depression (PSCAD). Methods： A total of 106 cases of PSCAD inpatients were randomly divided into Group A， Group B and Group C， with 35， 36 and 35 cases in each group respectively. The three groups were given routine basic therapy for stroke according to their disease conditions. Group A was treated with mind- regulating and constraint- resolving acupuncture method combined with Xiaoxingnao acupuncture method based on the oral administration of Flupentixol and Melitracen Tablets， Group B was treated with mind- regulating and constraint- resolving acupuncture method combined with Xiaoxingnao acupuncture method， and Group C was given oral administration of Flupentixol and Melitracen Tablets. The three groups were treated for 3 weeks. The scores of Pittsburgh Sleep Quality Index (PSQI)， Hamilton Depression Scale (HAMD)， Hamilton Anxiety Scale (HAMA)， National Institutes of Health Stroke Scale (NIHSS)， Barthel index (BI) and Stroke Specific Quality of Life Scale (SS-QOL) were evaluated before and after treatment. The clinical effects and the incidence of adverse reactions in the three groups were compared. Results：After 3 weeks of treatment，the total effective rate of clinical effect was 94.3% in Group A，higher than those of 69.4% in Group B and 71.4% in Group C (P＜ 0.05)， and there was no significant difference being found in the comparison of total effective rates between Group B and Group C (P＞0.05). After 1， 2 and 3 weeks of treatment， the scores of HAMD， HAMA and PSQI in Group A were decreased when compared with those before treatment (P＜0.05)，the scores of HAMD and HAMA in Group C were decreased when compared with those before treatment (P＜ 0.05)，the scores of HAMD，HAMA and PSQI in Group A were lower than those in Group B and C (P＜ 0.05). After 2 and 3 weeks of treatment， the scores of HAMD， HAMA and PSQI in Group B were decreased when compared with those before treatment (P＜0.05). After 3 weeks of treatment，the PSQI score in Group C was decreased when compared with that before treatment (P＜0.05). After 3 weeks of treatment，the score of HAMD in Group B was higher than that in Group C (P＜0.05). After 2 and 3 weeks of treatment，the scores of PSQI in Group B were lower than those in Group C (P＜0.05). In the follow-up 1 month after the end of treatment， the scores of HAMD and HAMA in Group B and C were increased when compared with those after 3 weeks of treatment (P＜0.05)，the PSQI score in Group C was increased when compared with that after 3 weeks of treatment (P＜0.05). NIHSS scores in the three groups were decreased when compared with those before treatment (P＜0.05)， scores of BI and SS- QOL were increased when compared with those before treatment (P＜0.05). The NIHSS score in Group A was lower than those in Group B and C，and the scores of BI and SS-QOL were higher than those in Group B and C (P＜0.05). The NIHSS score in Group B was lower than that in Group C，and scores of BI and SS-QOL were higher than those in Group C (P＜0.05). The incidence of adverse reactions in Group A was lower than that in Group B (P＜0.05)，and the incidence of adverse reactions in Group A and B was lower than that in Group C (P＜0.05). Conclusion：Based on routine therapy and Flupentixol and Melitracen Tablets，the application of mind- regulating and constraint- resolving acupuncture method combined with Xiaoxingnao acupuncture method has a definite curative effect in treating PSCAD， with few adverse reactions. It can significantly improve the anxiety and depression disorders of patients， and can also significantly improve the sleep quality，daily activities and quality of life of patients，enhance the comprehensive treatment effects，and promote the process of stroke rehabilitation.