Abstract： Objective： To observe the clinical effect of Weisu Granules combined with Rabeprazole Sodium for chronic non-atrophic gastritis (CAG). Methods：A total of 90 cases of CAG patients were divided into the control group and the treatment group according to the random number table method ， with 45 cases in each group. The control group was treated with Rabeprazole Sodium Enteric-Coated Tablets， and the treatment group was additionally treated with Weisu Granules based on the treatment of the control group. The changes in the scores of Visual Analogue Scale (VAS) and Activity of Daily Living Scale (ADL)， and the levels of prostaglandin E2 (PGE2)， epidermal growth factor (EGF)， inflammatory factors [tumor necrosis factor- α (TNF- α)， interleukin- 6 (IL- 6)]， gastrin (GAS)， and motilin (MTL) were compared between the two groups before treatment and after treatment. Clinical effects and the incidence of adverse reactions were analyzed in the two groups. Results：The total effective rate was 95.56% in the treatment group and 80.00% in the control group，the difference being significant between the two groups (P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of VAS and ADL between the two groups (P＞0.05). After treatment，VAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and ADL scores were increased when compared with those before treatment (P＜0.05)； the improvement of the two scores in the treatment group was more significant than that in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of TNF-α and IL-6 in serum between the two groups (P＞ 0.05). After treatment，the levels of TNF- α and IL- 6 in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of TNF- α and IL- 6 in the treatment group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of gastrin and motilin between the two groups (P＞0.05). After treatment， the levels of GAS and MTL in the two groups were increased when compared with those before treatment (P＜0.05)，and the two levels in the treatment group were higher than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of PGE2 and EGF between the two groups (P＞0.05). After treatment，levels of PGE2 in the two groups were increased when compared with those before treatment (P＜0.05)，and EGF levels were decreased when compared with those before treatment (P＜0.05)；the level of PGE2 in the treatment group was higher than that in the control group (P＜0.05)，and EGF level was lower than that in the control group (P＜0.05). The incidence of adverse reactions was 4.44% in the treatment group，significantly lower than that of 17.78% in the control group，the difference being significant (P＜0.05). Conclusion：Weisu Granules combined with Rabeprazole Sodium Enteric-Coated Tablets has a significant curative effect in the treatment of CAG，and can increase GAS and MTL，reduce pain degree and inflammatory responses，and improve activities of daliyliving with a relatively low incidence of adverse reactions.