Abstract： Objective： To analyze the evolution of syndromes and medication rules of diabetic kidney disease (DKD) of ancient physicians based on data mining. Methods：Based on the Chinese Medical Code， the database of disease-location syndrome elements，disease-nature syndrome elements and prescriptions of DKD was established. SPSS modeler 18.0 software was used for association rules analysis and network relationship mining. Gephi analysis software was used for visual analysis of knowledge maps， and SPSS26.0 software was used for clustering analysis of prescriptions and medicines. Results： A total of 167 articles related to nature of disease factors and locational syndrome factors of DKD were retrieved， including 9 disease-location syndrome elements，mainly kidney，followed by heart and lung，etc；and 16 disease-nature syndrome elements ， mainly fire (heat) ， followed by yin deficiency ， fluid (humor) consumption ， etc. The results of association rules analysis of disease- location and disease- nature syndrome elements of disease factors of DKD showed that the following elements were closely related： stomach-fire (heat)，stomach and kidney-fire (heat)，stomach and heart-fire (heat)，stomach and lungfire (heat)； the results of network relationship mining showed that the following elements were closely related：kidney-fire (heat)，kidney-yin deficiency，and kidney-fluid (humor) consumption. The results of visual analysis of knowledge maps showed that the disease- location syndrome elements were most expressed in kidney，heart，lung，spleen，stomach and liver，and the disease-nature syndrome elements were most expressed in fire (heat)， yin deficiency， qi deficiency， fluid (humor) consumption， dryness， blood deficiency，yang deficiency，phlegm，etc；modularization showed that kidney，heart and lung form a group of elements with similar co-occurrence levels，and yang deficiency，phlegm and dampness form a group of elements with similar co-occurrence levels. A total of 416 prescriptions were retrieved. According to the frequency of use，46 commonly- used drugs were obtained，mainly with cold，warm and mild as the medicinal nature， with sweet， bitter and acrid as medicinal flavors， mainly with kidney， lung and heart as channel entry，and with medicines mainly for supplementing deficiency，clearing heat，promoting urination and percolating dampness，and astringency. The cluster analysis results showed that there were 6 core prescriptions， including Liuwei Dihuang Pills， Shengmai Decoction， Baifuling Pills， Sangpiaoxiao Powder， Shugandihuang Powder， Jinkui Shenqi Pills， Jisheng Shenqi Pills， Siwu Decoction， etc. Conclusion：The syndrome of DKD generally shows the evolution rules of“heat-deficiency-blood stasis”. Most of the heat belongs to deficiency-heat，with dampness as the core and blood stasis throughout. The primary therapeutic principles are to boost qi and nourish yin，clear heat，moisten dryness，promote fluid production， fortify the spleen and supplement the kidney， remove dampness， promote urination and alleviate swelling，and invigorate blood and dissolve stasis.