Abstract: Objective: To observe the clinical effect of prescription for constipation combined with wheat cellulose for senile functional constipation with qi deficiency syndrome. Methods:A total of 94 cases of senile patients with functional constipation with qi deficiency syndrome were divided into the control group and the observation group according to the random number table method, with 47 cases in each group. The control group was treated with wheat cellulose, and the observation group was additionally treated with prescription for constipation based on the treatment of the control group. Both groups were treated for 2 weeks. The scores of Cleveland Constipation Scale (CCS),Patient Assessment of Constipation Quality of Life (PAC-QOL) and Bristol Stool Form Scale (BSFS),and the levels of motilin (MTL) and gastrin (GAS) in serum before and after treatment as well as the clinical effects and the incidence of adverse reactions were compared between the two groups. Results:After treatment,the total effective rate was 95.74% in the observation group, higher than that of 82.98% in the control group (P<0.05). After treatment, the scores of CCS and PAC- QOL in the two groups were decreased when compared with those before treatment (P<0.05), and BSFS scores were increased when compared with those before treatment (P<0.05);the scores of CCS and PAC-QOL in the observation group were lower than those in the control group (P<0.05), and BSFS score was higher than that in the control group (P<0.05). After treatment, the levels of MTL and GAS in serum in the two groups were increased when compared with those before treatment (P<0.05),and the levels of MTL and GAS in serum in the observation group were higher than those in the control group (P<0.05). During the treatment,the incidence of adverse reactions was 8.51% in the observation group and 4.26% in the control group,there being no significant difference (P>0.05). Conclusion: Prescription for constipation combined with wheat cellulose for senile functional constipation with qi deficiency syndrome has a better curative effect than simple treatment of wheat cellulose, and it can significantly improve the clinical symptoms and quality of life of patients with good safety.