Abstract：Objective：To observe the effect of Liuyi powder on the prevention of stress injury in patients with paraplegia. Methods：A total of 60 patients with paraplegia were divided into the control group and the observation group，30 cases in each group. The two groups received nursing care according to the conventional methods. The control group applied Saifurun cream on the locally compressed parts， and the observation group applied Liuyi powder on the compressed skin. The cooperation degree of patients in the two groups was compared，and the incidence of stress injury at Stage 1 and Stage 2 in the two groups were compared. Results： When compared with that in the control group， the overall coordination in the observation group was better(P＜0.05). The total incidence of stress injury in the observation group was lower than that in the control group after nursing at Stage 1 and Stage 2(P＜0.05). Conclusion：The application of Liuyi powder based on nursing for patients with paraplegia can effectively reduce the incidence of stress injury at Stage 1 and Stage 2，which can better alleviate the pain of patients and improve the quality of life.