Abstract： This article introduces Professor YE Liqun's clinical experience in treating polycystic ovary syndrome （PCOS） of liver depression and kidney deficiency type based on state-targeted theory. The state-targeted theory integrates the macroscopic regulation of Chinese medicine with the microscopic precision treatment of modern medicine，emphasizing comprehensive control of the disease. Professor YE Liqun believes that PCOS of liver depression and kidney deficiency type primarily involves liver depression state and kidney deficiency state. The treatment should focus on regulating qi movement and tonifying the kidney. Additionally，through the menstrual cycle regulation method， targeted prescriptions and medications are selected according to different stages of the patient's menstrual cycle. This precise treatment addresses both the symptomatic and root causes， improving clinical symptoms and biochemical indicators such as hyperandrogenism and insulin resistance in patients with PCOS of liver depression and kidney deficiency type.