Abstract： Objective： To observe the clinical effect of acupuncture and moxibustion combined with Diclofenac Sodium Sustained-Release Capsules for pain in neck， shoulder， waist， and leg. Methods： A total of 200 cases of patients with pain in neck， shoulder， waist， and leg were selected and randomly divided into the observation group and the control group， with 100 cases in each group. The control group was routinely given Diclofenac Sodium Sustained-Release Capsules， and the observation group was additionally treated with acupuncture and moxibustion based on the treatment of the control group. Clinical effects， traditional Chinese medicine （TCM） syndrome scores， pain severity [Visual Analogue Scale （VAS） scores]，motor function [scores of Fugl-Meyer Motor Function Assessment Scale（ FMA）]，and sleep quality [Pittsburgh Sleep Quality Index（ PSQI）] were observed and compared between the two groups. Results： The total effective rate was 93.00%（93/100） in the observation group and 84.00%（84/100） in the control group，the difference being significant （P＜0.05）. After treatment，the scores of main and secondary symptoms of TCM syndromes in the two groups were declined （P＜0.05），and the two scores in the observation group were lower than those in the control group （P＜0.05）. Before treatment，there was no significant difference in VAS scores between the two groups （P＞0.05）. After 3 and 10 days of treatment，VAS scores in the two groups were reduced compared to the previous time point in the same group （P＜0.05），and VAS scores in the observation group were lower than those in the control group at the same time point （P＜0.05）. After treatment，FMA scores in the two groups were increased when compared with those before treatment （P＜0.05）， and PSQI scores were declined when compared with those before treatment （P＜0.05）；FMA score in the observation group was higher than that in the control group （P＜0.05），and PSQI score in the observation group was lower than that in the control group （P＜0.05）. Conclusion：In the treatment of pain in neck， shoulder， waist， and leg， acupuncture and moxibustion of TCM can effectively improve the TCM syndrome of patients，reduce the severity of pain，improve the clinical curative effect，and help improve their motor function and sleep quality.