Abstract： This article summarizes and introduces the Qihuang Scholar， Professor WANG Xinzhi's clinical experience in treating insomnia with Huanglian Decoction. Professor WANG Xinzhi believes that the main etiology of insomnia in modern people are the disharmony of the viscera's cold and heat and the imbalance of yin and yang，which are closely related to the liver's failure to govern the free flow of qi and the disharmony of the spleen and stomach. The pathological location is in the heart and is closely related to the liver， spleen （stomach）， and kidney. The core pathogenesis is the upper heat and lower cold and the imbalance of yin and yang. He advocates treating insomnia from the perspective of the liver and spleen，with harmonizing cold and heat and balancing yin and yang as the basic therapeutic methods. Huanglian Decoction is selected as the main formula for flexible modification and treatment， which can achieve good therapeutic effects.