Abstract： Objective： To observe the clinical effect of Liangxue Xiaofeng Powder combined with Halometasone Cream in the treatment of psoriasis vulgaris with blood-heat and wind-excess syndrome. Methods：A total of 94 patients with psoriasis vulgaris of blood-heat and wind-excess syndrome，treated at the Department of Dermatology of General Hospital of Pingmei Shenma Group from February 2022 to July 2023， were selected as the study subjects. They were divided into the observation group and the control group using a random number table method，with 47 cases in each group. The control group was treated with Halometasone Cream alone， while the observation group was treated with Halometasone Cream combined with modified Liangxue Xiaofeng Powder. Both groups were treated continuously for four weeks. The clinical efficacy， Psoriasis Area and Severity Index （PASI）， levels of inflammatory factors [interleukin- 17 （IL-17） and interferon-gamma （IFN-γ）]，skin barrier function，incidence of adverse reactions，and recurrence rates were compared between the two groups before and after treatment. Results： After treatment， the total effective rate was 91.49% （43/47） in the observation group， significantly higher than that of 76.60% （36/47） in the control group （P＜0.05）. After treatment， the PASI scores in both groups were decreased （P＜0.05）， and the observation group had lower PASI scores than the control group （P＜0.05）. After treatment，the levels of IL-17 and IFN-γ in both groups were decreased （P＜0.05）， and the observation group had lower levels of IL-17 and IFN-γ than the control group （P＜0.05）. After treatment， the sebum content and stratum corneum hydration in both groups were increased （P＜0.05）， and the observation group had higher sebum content and stratum corneum hydration than the control group （P＜0.05）. During the treatment period， the incidence of adverse reactions was 10.64% （5/47） in the observation group，and 6.38% （3/47） in the control group，with no significant difference between the two groups （P＞ 0.05）. After six months of follow-up，the recurrence rate was 23.26% （10/43） in the observation group，significantly lower than that of 44.44%（ 16/36） in the control group（ P＜0.05）. Conclusion：The combination of Liangxue Xiaofeng Powder and Halometasone Cream in the treatment of psoriasis vulgaris with blood-heat and wind-excess syndrome can improve clinical efficacy， inhibit inflammatory responses， promote the recovery of skin barrier function， and reduce the recurrence rates.