补肾活血法联合西药治疗先兆流产合并绒毛膜下血肿临床疗效Meta 分析
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R714.21

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罗颂平全国名中医传承工作室、罗颂平全国名老中医药专家传承工作室(国中医药办人教函〔2022〕245号);广东省本科高校教学质量与教学改革工程(粤教高函〔2021〕29号)


Meta Analysis of the Clinical Effect of Bushen Huoxue Therapy Combined with Western Medicine for Threatened Abortion Complicated with Subchorionic Hematoma
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    摘要:

    目的:采用Meta分析评价补肾活血法联合西药治疗先兆流产合并绒毛膜下血肿(SCH) 的临床疗 效及用药规律。方法:通过计算机检索知网、中国生物医学文献服务系统、维普数据库、万方数据库、 PubMed、Embase和Cochrane Library等数据库,收集关于补肾活血法联合西药(试验组) 对比单纯西药(对照 组) 治疗先兆流产合并SCH的临床随机对照试验(RCTs)。采用Cochrane手册偏倚风险工具进行文献质量评 价,并运用RevMan 5.4、Stata 18进行Meta分析。结果:共纳入33篇RCTs,包含2 608例患者,其中试验组 1 324例,对照组1 284例。对照组治疗药物分别为地屈孕酮片、黄体酮胶囊/注射液、维生素E软胶囊、注射 用绒促性素、氨甲苯酸注射液、维生素K注射液、间苯三酚注射液、肾上腺色腙片、低分子肝素钙注射液;试 验组在对照组的基础上服用寿胎丸加减(桑寄生、续断、阿胶、菟丝子,不少于其中3味),加活血化瘀类中 药。本研究共涉及48味中药,其中活血化瘀类中药15味,其使用频次≥5次的药物及其剂量依次为当归(5~ 15 g)、三七(1.5~6 g)、丹参(6~30 g)、蒲黄炭(10~12 g)。Meta分析结果显示,与对照组比较,试验组 总有效率及痊愈率更高(P<0.001),治疗后血肿面积更小(P<0.001),治疗后缩小的血肿面积更大(P< 0.001),治疗后血肿消失时间及阴道流血停止时间更短(P<0.001)。结论:补肾活血法联合西药治疗先兆流 产合并SCH较单纯西药临床疗效更佳,活血化瘀类中药多用当归、三七、丹参、蒲黄炭等。

    Abstract:

    Abstract:Objective:To evaluate the clinical effect and medication rules of Bushen Huoxue therapy combined with western medicine in the treatment of threatened abortion complicated with subchorionic hematoma (SCH) through a Meta-analysis. Methods:Randomized controlled trials (RCTs) comparing the combination of Bushen Huoxue therapy and western medicine (the trial group) with western medicine alone (the control group) for the treatment of threatened abortion complicated with SCH were collected by searching databases such as CNKI,CBM,VIP,Wanfang,PubMed, Embase,and Cochrane Library. The Cochrane risk of bias tool was used for literature quality assessment,and RevMan 5.4 and Stata 18 were employed for Meta-analysis. Results:A total of 33 RCTs involving 2 608 patients were included, with 1 324 patients in the trial group and 1 284 in the control group. The western medicines used in the control group included Dydrogesterone Tablets,Progesterone Capsules/Injection,Vitamin E Soft Capsules,Chorionic Gonadotropin for Injection, Aminomethylbenzoic Acid Injection, Vitamin K Injection, Phloroglucinol Injection, Carbazochrome Tablets, and Low Molecular Weight Heparin Calcium Injection. The trial group received modified Shoutai Pills (containing at least three of the following: Taxilli Herba, Dipsaci Radix, Asini Corii Colla, and Cuscutae Semen) combined with blood-activating and stasis-resolving herbs in addition to the control group. A total of 48 Chinese herbs were involved, including 15 blood-activating and stasis-resolving herbs. The blood-activating and stasisresolving herbs with a use frequency of ≥ 5 times and their dosages were as follows:Angelicae Sinensis Radix( 5-15 g), Notoginseng Radix et Rhizoma (1.5-6 g),Salviae Miltiorrhizae Radix et Rhizoma (6-30 g),and Carbonized Typhae Pollen (10-12 g). Meta-analysis results showed that, compared with the control group, the trial group had a higher total effective rate and cure rate (P<0.001),a smaller hematoma area after treatment (P<0.001),a larger reduction in hematoma area after treatment (P<0.001), and shorter time for hematoma disappearance and vaginal bleeding cessation (P<0.001). Conclusion: The combination of Bushen Huoxue therapy and western medicine is more effective than western medicine alone in the treatment of threatened abortion complicated with SCH. Blood-activating and stasis-resolving herbs such as Angelicae Sinensis Radix, Notoginseng Radix et Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma,and Carbonized Typhae Pollen are commonly used.

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何雪,黄蕾,詹群璋,许丽绵,曹蕾.补肾活血法联合西药治疗先兆流产合并绒毛膜下血肿临床疗效Meta 分析[J].新中医,2025,57(12):18-27

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  • 在线发布日期: 2025-06-26
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