穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎伴Hp 感染临床研究
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R573.3+2;R245.9+1

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丽水市公益性科研计划项目(2023GYX59)


Clinical Study on Catgut Embedment in Acupoint Assisting Quadruple Therapy for Chronic Atrophic Gastritis Complicated with Hp Infection of Spleen-Stomach Weakness Type
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    摘要:

    目的:观察穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎(CAG) 伴幽门螺杆菌(Hp) 感染的临床疗效。方法:选取112例脾胃虚弱型CAG伴Hp感染患者,采用随机数字表法分为对照组(予四联 疗法治疗) 和观察组(予穴位埋线辅助四联疗法治疗) 各56例。治疗结束后,2组均随访5个月。比较2组临 床疗效、胃黏膜功能指标[胃泌素17(G-17)、胃蛋白酶原Ⅰ (PGⅠ)]、健康调查简表(SF-36) 评分、中 医证候积分、病理评分、不良反应发生率及复发率。结果:总有效率观察组96.43%,高于对照组80.36%(P< 0.05)。治疗后3个月,2组血清G-17、PGⅠ水平均较治疗前升高(P<0.05),观察组上述2项指标水平均高于 对照组(P<0.05)。治疗后1个月、3个月,2组SF-36评分均较治疗前升高(P<0.05),观察组SF-36评分 均高于同期对照组(P<0.05)。治疗后3个月,2组中医证候积分均较治疗前降低(P<0.05),观察组中医证 候积分低于对照组(P<0.05)。治疗后5个月,2组病理评分均较治疗前下降(P<0.05),观察组病理评分低 于对照组(P<0.05)。不良反应发生率观察组8.93%,与对照组3.57%比较,差异无统计学意义(P>0.05)。 治疗后5个月,复发率观察组1.85%,低于对照组15.56%(P<0.05)。结论:穴位埋线辅助四联疗法治疗脾胃 虚弱型CAG 伴Hp感染,可减轻患者的临床症状,改善胃黏膜功能,提高生活质量,降低复发率,且安全 性好。

    Abstract:

    Abstract: Objective: To observe the clinical effect of catgut embedment in acupoint assisting quadruple therapy on chronic atrophic gastritis (CAG) complicated with helicobacter pylori (Hp) infection of spleen-stomach weakness type. Methods: A total of 112 cases of CAG complicated with Hp infection patients of spleen-stomach weakness type were selected and divided into the control group (treated with quadruple therapy) and the observation group (treated with catgut embedment in acupoint assisting quadruple therapy),with 56 cases in each group,using a random number table method. After treatment, both groups were followed up for five months. Compared with the clinical efficacy,gastric mucosal function indicators [gastrin 17 (G-17) and pepsinogenⅠ(PGⅠ),36-Item Short Form Health Survey (SF-36) scores, traditional Chinese medicine (TCM) syndrome scores,pathological scores,incidence of adverse reactions, and recurrence rates between the two groups. Results: The total effective rate was 96.43% in the observation group, which was higher than that of 80.36% in the control group (P<0.05). Three months after treatment,the levels of G-17 and PGⅠ in serum in both groups were increased when compared with those before treatment (P<0.05),and the levels of the above two indicators in the observation group were higher than those in the control group (P<0.05). One month and three months after treatment,the SF-36 scores in both groups were increased when compared to those before treatment (P<0.05),and the SF-36 score in the observation group was higher than that in the control group during the same period (P<0.05). Three months after treatment, the TCM syndrome scores in the two groups were decreased when compared to those before treatment (P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group (P<0.05). Five months after treatment,the pathological scores in both groups were declined when compared to those before treatment (P<0.05), and the pathological score in the observation group was lower than that in the control group (P<0.05). The incidence of adverse reactions was 8.93% in the observation group,and 3.57% in the control group,there being no significant difference (P>0.05). Five months after treatment, the recurrence rate was 1.85% in the observation group, lower than that of 15.56% in the control group (P<0.05). Conclusion: Catgut embedment in acupoint assisting quadruple therapy can alleviate clinical symptoms, improve gastric mucosal function, improve quality of life,and reduce recurrence rates in patients with CAG accompanied by Hp infection with spleen-stomach weakness type,which is safe.

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刘兵,钱小情,李丽乐,王健,杨艳.穴位埋线辅助四联疗法治疗脾胃虚弱型慢性萎缩性胃炎伴Hp 感染临床研究[J].新中医,2024,56(18):157-161

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  • 在线发布日期: 2024-09-27
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