清心定志汤联合高频rTMS 治疗精神分裂症疗效观察及对脑神经营养因子的影响
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R749.3

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衢州市科学技术局课题(2021106)


Observation on the Therapeutic Effect of Qingxin Dingzhi Decoction Combined with High-Frequency rTMS in the Treatment of Schizophrenia and Its Impact on Brain Neurotrophic Factors
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    摘要:

    目的:观察清心定志汤联合高频经颅磁刺激(rTMS) 治疗精神分裂症(SP) 的临床疗效及对脑神 经营养因子水平的影响。方法:选取106例SP患者为研究对象,以随机数字表法分为试验组与对照组各53例。 2组均给予基础治疗,对照组加用高频rTMS治疗,试验组在对照组基础上加用清心定志汤治疗,2组均治疗 4周。比较2组临床疗效、中医证候评分、阳性与阴性综合征量表(PANSS) 评分、阴性症状量表(SANS) 评 分及脑神经营养因子[脑源性神经营养因子(BDNF)、胶质原性神经营养因子(GDNF) ]水平。结果:试验组 总有效率为94.34%,对照组为77.36%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分 均较治疗前降低(P<0.05),且试验组中医证候评分低于对照组(P<0.05)。治疗后,2组PANSS、SANS评分 均较治疗前降低(P<0.05),且试验组PANSS、SANS评分均低于对照组(P<0.05)。治疗后,2组血清BDNF、 GDNF水平均较治疗前升高(P<0.05),且试验组BDNF、GDNF水平均高于对照组(P<0.05)。结论:清心定 志汤联合高频rTMS治疗SP疗效显著,有利于减轻患者中医证候,改善患者阴性症状,其作用机制可能与上调 脑神经营养因子水平有关。

    Abstract:

    Abstract:Objective:To observe the clinical efficacy of Qingxin Dingzhi Decoction combined with highfrequency transcranial magnetic stimulation (rTMS) in the treatment of schizophrenia (SP) and its impact on brain neurotrophic factor levels. Method: A total of 106 patients with SP were selected as the study subjects and randomly divided into an trial group and a control group,with 53 cases in each group,using a random number table method. Both groups were given basic treatment, while the control group was treated with high-frequency rTMS. In the trial,Qingxin Dingzhi Decoction was added to the control group for treatment. Both groups were treated for four weeks. Compare the clinical efficacy,traditional Chinese medicine (TCM) syndrome scores, positive and negative symptom scale (PANSS) scores, negative symptom scale (SANS) scores, and levels of brain-derived neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF) between the two groups. Results:The total effective rate of the trial group was 94.34%, while that of the control group was 77.36%. The difference between the two groups was statistically significant (P<0.05). After treatment, the TCM syndrome scores of both groups decreased compared to those before treatment (P<0.05),and the TCM syndrome scores of the trial group were lower than those of the control group (P<0.05). After treatment, the PANSS and SANS scores of both groups decreased compared to before treatment (P<0.05), and the PANSS and SANS scores of the trial group were lower than those of the control group (P<0.05). After treatment,the levels of serum BDNF and GDNF in both groups increased compared to those before treatment (P<0.05),and the levels of BDNF and GDNF in the trial group were higher than those in the control group (P<0.05). Conclusion: The combination of Qingxin Dingzhi Decoction and high-frequency rTMS has a significant therapeutic effect on SP, which is beneficial for reducing TCM syndrome and improving negative symptoms in patients. Its mechanism of action may be related to the upregulation of brain neurotrophic factors.

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徐家庭,兰智勇,叶露雯,勾东方.清心定志汤联合高频rTMS 治疗精神分裂症疗效观察及对脑神经营养因子的影响[J].新中医,2024,56(18):55-59

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  • 在线发布日期: 2024-09-27
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