小柴胡汤加减联合西药治疗围绝经期失眠症临床研究
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R256.23

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Clinical Study on Modified Xiaochaihu Decoction Combined with Western Medicine for Perimenopausal Insomnia
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    摘要:

    目的:观察小柴胡汤加减联合西药治疗围绝经期失眠症的临床疗效及对睡眠质量、激素的影响。 方法:回顾性选择2022年10月—2023年10月收治的围绝经期失眠症患者154例,根据治疗方式的不同分为对 照组、观察组各77例。对照组给予常规西药治疗,观察组在对照组基础上加用小柴胡汤加减治疗。比较2组临 床疗效及治疗前后中医证候积分、匹兹堡睡眠质量指数(PSQI) 评分、汉密尔顿焦虑量表(HAMA) 评分、睡 眠潜伏期、睡眠效率、觉醒时间、睡眠总时间及血清激素水平。结果:观察组总有效率92.21%,高于对照组 80.52%(P<0.05)。治疗后,2组中医证候积分、PSQI评分、HAMA评分及血清促黄体生成素(LH)、促卵泡 生成素(FSH) 水平较治疗前降低(P<0.05),睡眠潜伏期、觉醒时间缩短(P<0.05);且观察组睡眠潜伏期、 觉醒时间短于对照组(P<0.05),中医证候积分、PSQI 评分、HAMA 评分及血清LH、FSH 水平低于对照 组(P<0.05)。2组治疗后睡眠效率及血清雌二醇(E2) 水平较治疗前升高(P<0.05),睡眠总时间延长(P< 0.05);观察组睡眠效率及血清E2水平高于对照组(P<0.05),睡眠总时间长于对照组(P<0.05)。结论:小柴 胡汤加减联合西药治疗围绝经期失眠症,能调节患者睡眠结构参数与激素水平,改善睡眠质量,减轻焦虑情 绪,疗效显著。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Xiaochaihu Decoction for perimenopausal insomnia and its effects on sleep quality and hormones. Methods:A total of 154 cases of patients with perimenopausal insomnia who were admitted from October 2022 to October 2023 were retrospectively selected and divided into the control group and the observation group by different treatment methods, with 77 cases in each group. The control group was given conventional western medicine treatment, and the observation group was additionally treated with modified Xiaochaihu Decoction on the basis of the treatment of the control group. Clinical effects, as well as scores of traditional Chinese medicine (TCM) syndrome,Pittsburgh Sleep Quality Index (PSQI),Hamilton Anxiety Rating Scale (HAMA), and sleep latency,sleep efficiency,wakefulness time,and total sleep time,and serum hormone levels before and after treatment were compared between the two groups. Results:The total effective rate was 92.21% in the observation group, higher than that of 80.52% in the control group (P<0.05). After treatment, TCM syndrome scores, PSQI scores, HAMA scores, and levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in serum were declined when compared with those before treatment, and sleep latency and wakefulness time were shortened (P<0.05); sleep latency and wakefulness time in the observation group were shorter than those in the control group (P<0.05),and TCM syndrome scores, PSQI scores, HAMA scores, and levels of LH and FSH in serum in the observation group were lower than those in the control group (P<0.05). After treatment,sleep efficiency and levels of serum estradiol (E2) in the two groups were increased when compared with those before treatment, and total sleep time was prolonged (P<0.05); sleep efficiency and levels of serum E2 in the observation group were higher than those in the control group (P<0.05), and total sleep time in the observation group was longer than that in the control group (P<0.05). Conclusion:Modified Xiaochaihu Decoction combined with western medicine for perimenopausal insomnia can regulate sleep structural parameters and hormone levels,improve sleep quality,and alleviate anxiety,with significant therapeutic effects.

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徐景悦,毛意,厉志莲,张毅.小柴胡汤加减联合西药治疗围绝经期失眠症临床研究[J].新中医,2024,56(18):8-12

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  • 在线发布日期: 2024-09-27
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